Studies on Anti-hyperglycemic Effect of Ethanolic Extracts from (Retz.)Schult
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Studies on Anti-hyperglycemic Effect of Ethanolic Extracts from (Retz.)Schult
Chinese Journal of Experimental Traditional Medical FormulaeVol. 13, Issue 1, Pages: 32-34(2007)
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Published:2007
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ZHEN Han-shen, LIANG Jie, Zhou Fang. Studies on Anti-hyperglycemic Effect of Ethanolic Extracts from (Retz.)Schult[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(1): 32-34.
DOI:
ZHEN Han-shen, LIANG Jie, Zhou Fang. Studies on Anti-hyperglycemic Effect of Ethanolic Extracts from (Retz.)Schult[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(1): 32-34.DOI:
Studies on Anti-hyperglycemic Effect of Ethanolic Extracts from (Retz.)Schult
Objective:To study the anti-hyperglycemic effect of Gymnema sylvestre(Retz.)Schult 95% Ethanolic Extracts(GSEE).Method:Normal mice
alloxan-induced diabetic mice
adrenaline-induced hyperglycemic mice were used.The anti-hyperglycemic action was studied with radio-immunoassay and glucoseoxidase.Result:High dosage of GSEE could decrease fasted blood sugar in normal mice.It could increase serum insulin level
decrease fasted blood sugar in alloxan-induced diabetic mice.It could also decrease fasted blood sugar in adrenaline-induced hyperglycemic mice.It could improve glucose tolerance in normal mice
and the duration was about 1 hour.Conclusion:GSEE has obvious anti-hyperglycemic effect in alloxan-induced diabetic mice and adrenaline-induced hyperglycemic mice.It could improve glucose tolerance in normal mice.Its mechanism is stimulating of insulin secretion from β cells.
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ZHEN Han-shen
LIANG Jie
ZHOU Fang
GE Zheng-yan
JIN Long
YAN Ai-guo
DONG Xiao-xia
LI Hong-kun
Related Institution
Department of Pharmacy,Guangxi Traditional Chinese Medical University
广西中医学院药学院 广西南宁530001
Hospital of Chengdu University of Traditional Chinese Medicine
First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine
Guizhou Province Natural Medicinal Resources High-Efficacy Application Engineering Center