The Effect of Sheng-Jiang Capsule on 5-HT in Vomiting Pigeon due to Chemotherapy

XU Wei; SUN Wei-feng; CHEN Zhi-huang; WEI song; LI Li

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The Effect of Sheng-Jiang Capsule on 5-HT in Vomiting Pigeon due to Chemotherapy

更新时间：2024-01-04

- The Effect of Sheng-Jiang Capsule on 5-HT in Vomiting Pigeon due to Chemotherapy
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 13, Issue 4, Pages: 45-47(2007)
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- Published：2007
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XU Wei, SUN Wei-feng, CHEN Zhi-huang, et al. The Effect of Sheng-Jiang Capsule on 5-HT in Vomiting Pigeon due to Chemotherapy[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(4): 45-47.
DOI：

XU Wei, SUN Wei-feng, CHEN Zhi-huang, et al. The Effect of Sheng-Jiang Capsule on 5-HT in Vomiting Pigeon due to Chemotherapy[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(4): 45-47. DOI：

摘要

目的:观察升降胶囊对顺铂所致家鸽呕吐的作用

探讨其防治呕吐的机制。方法:采用家鸽腹腔注射顺铂制造呕吐模型

观察家鸽呕吐频率及呕吐潜伏期;用高效液相色谱-电化学检测法(HPLC-ED)检测家鸽血清、十二指肠组织中5-羟色胺(5-HT)的含量。结果:升降胶囊对化疗致呕家鸽有明确的止呕作用。升降胶囊组家鸽血清和十二指肠组织中5-HT的含量显著减少(P<0.05)。结论:升降胶囊止呕的机制与降低5-HT水平有关。

Abstract

Objective:To observe the effect of Sheng-Jiang Capsule on treating cisplatin-induced pigeon's vomiting

and explore the functional mechanism in preventing and treating vomiting.Method:The test was designed to make animal models by injecting the chemical medicine cisplatin in pigeon's abdomen

observing the vomiting times and delitescence

and measuring the levels of 5-hydroxytryptamine(5-HT)in pigeon's blood and duodenum tissue by high performance liquid chromatography with electrochemical detection(HPLC-ED).Result:Sheng-Jiang Capsule can obviously decrease the vomiting times and delay the vomiting delitescence of the pigeons

the 5-HT contents of blood and duodenum tissue in the groups of Sheng-Jiang Capsule are markedly lower than that of model group(P<0.05).Conclusion:Possible mechanism of Sheng-Jiang Capsule is to decrease the level of 5-HT.

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