Application of Modified Isobologram Method in Quantitative Analysis for the Interaction of Saponins of Fisch and A.DC
|更新时间:2024-01-04
|
Application of Modified Isobologram Method in Quantitative Analysis for the Interaction of Saponins of Fisch and A.DC
Chinese Journal of Experimental Traditional Medical FormulaeVol. 13, Issue 3, Pages: 40-42(2007)
作者机构:
作者简介:
基金信息:
DOI:
CLC:
Published:2007
稿件说明:
移动端阅览
LIU Bin, Qi Yun, SONG Yang, et al. Application of Modified Isobologram Method in Quantitative Analysis for the Interaction of Saponins of Fisch and A.DC[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(3): 40-42.
DOI:
LIU Bin, Qi Yun, SONG Yang, et al. Application of Modified Isobologram Method in Quantitative Analysis for the Interaction of Saponins of Fisch and A.DC[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(3): 40-42.DOI:
Application of Modified Isobologram Method in Quantitative Analysis for the Interaction of Saponins of Fisch and A.DC
Objective:To evaluate the expectorant and anti-inflammatory effects of the combinations of saponins of Glycyrrhiza uralensis Fisch(GS) and Platycodon grandiflorum A.DC(PS).Methods:The phenol drain model
xylene-induced mouse ear edema model and PLA2-induced mouse paw edema model were used
and the interaction between these two agents was evaluated by modified isobologram method.Result:With the decrease of total dose
the trend of interaction from antagonism to synergism was observed
and synergism or additivity was obtained at low effective doses.Conclusion:At fixed ratio
the total dose would affect the herbal interactive effects.