Effects of Sesamin on the Hemodynamics,NO and ET-1 in Renal Hypertensive Rats
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Effects of Sesamin on the Hemodynamics,NO and ET-1 in Renal Hypertensive Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 13, Issue 4, Pages: 33-36(2007)
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Published:2007
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LI Xian-wei1, YANG Jie-ren1, ZHU Xiao-jun2. Effects of Sesamin on the Hemodynamics,NO and ET-1 in Renal Hypertensive Rats[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(4): 33-36.
DOI:
LI Xian-wei1, YANG Jie-ren1, ZHU Xiao-jun2. Effects of Sesamin on the Hemodynamics,NO and ET-1 in Renal Hypertensive Rats[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(4): 33-36.DOI:
Effects of Sesamin on the Hemodynamics,NO and ET-1 in Renal Hypertensive Rats
Objective:To investigate the effects of sesamin on the hemodynamics
NO and ET-1 of myocardium in renal hypertensive rats.Methods:The two-kidney and one-clip rat model was established.Hemodynamics parameters
left ventricular weight index(LVWI)
reactive oxygen species(ROS)level
myocard nitri coxide(NO) and Endothelin-1(ET-1) concentration were measured after administration with sesamin for six weeks.The linear correlations between LVWI and NO
ET-1 were respectively analyzed.Results:Sesamin 100 mg·kg-1 group significantly decreased MAP
LVSP
LVEDP
LVWI
ROS and ET-1(P<0.01)
increased ±dp/dtmax
ACF and NO(P<0.05
P<0.01).In addition
LVWI was correlated negatively with NO(r=-0.626
P<0.01)and positively with ET-1(r=0.542
P<0.01).Conclusions:Sesamin can obviously improve the hemodynamics.These effects may relate to their antioxygen effect and effect of increasing the concentration of myocard NO and decreasing the content of myocard ET-1.