Effect of Dingzhixiaowan on E and Dentate Gyrus Neural Stem Cell of Female Depressed Rats

YAN Xing-yu; WANG De-shan; SHAN De-hong

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Effect of Dingzhixiaowan on E and Dentate Gyrus Neural Stem Cell of Female Depressed Rats

更新时间：2024-01-04

- Effect of Dingzhixiaowan on E and Dentate Gyrus Neural Stem Cell of Female Depressed Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 13, Issue 6, Pages: 43-45(2007)
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- Published：2007
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YAN Xing-yu, WANG De-shan, SHAN De-hong. Effect of Dingzhixiaowan on E and Dentate Gyrus Neural Stem Cell of Female Depressed Rats[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(6): 43-45.
DOI：

YAN Xing-yu, WANG De-shan, SHAN De-hong. Effect of Dingzhixiaowan on E and Dentate Gyrus Neural Stem Cell of Female Depressed Rats[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(6): 43-45. DOI：

摘要

目的:研究定志小丸的抗抑郁机制。方法:40只体重和行为学得分相近的雌性大鼠分为正常对照组、抑郁症模型组、生理盐水组和定志小丸组

open field法检测行为学得分

ELISA法检测血清雌二醇(E2)含量

免疫组化技术检测齿状回神经干细胞(NSC)增殖情况。结果:与正常对照组比较

模型组和盐水组行为学得分及血清E2含量显著下降

NSC增殖明显减少

定志小丸组行为学得分及血清E2含量与正常对照组比无明显变化

NSC增殖显著增加。结论:定志小丸的抗抑郁作用与其维持E2正常分泌和促进NSC增殖有关。

Abstract

Objective:To study the anti-depression mechanism of dingzhixiaowan.Methods: 40 female rats of same weight and behavior points were divided into the control

the depression model group(model group)

saline group and dingzhixiaowan group(Chinese medicine group).The behavior points were measured by open-field method.Serum E2 levels were detected with ELISA.The proliferation levels of neural stem cells(NSC) in dentate gyrus were detected by immunohistochemistry technique.Results:Compared with the control

the behavior points and serum E2 levels of the model group and saline group decreased obviously

and those of the Chinese medicine group did not change markedly.Compared with the control

the proliferation levels of NSC of the model group and saline group decreased obviously

while that of the Chinese medicine group increased markedly.Conclusion: Dingzhixiaowan has the anti-depression acting by maintaining the normal E2 level and increasing proliferation of the NSC.

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