Experimental Study of Succus Bambusae on Antitussive and Expectorant Effect

CAI Hua-fang

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Experimental Study of Succus Bambusae on Antitussive and Expectorant Effect

更新时间：2024-01-04

- Experimental Study of Succus Bambusae on Antitussive and Expectorant Effect
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 13, Issue 5, Pages: 43-44(2007)
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- Published：2007
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CAI Hua-fang. Experimental Study of Succus Bambusae on Antitussive and Expectorant Effect[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(5): 43-44.
DOI：

CAI Hua-fang. Experimental Study of Succus Bambusae on Antitussive and Expectorant Effect[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(5): 43-44. DOI：

摘要

目的:观察鲜竹沥的镇咳祛痰作用。方法:采用17.5%枸椽酸和28%氨水喷雾

分别造成豚鼠、小鼠咳嗽模型

观察鲜竹沥的镇咳作用;采用小鼠气管酚红分泌试验、兔离体气管黏液纤毛运动试验

观察鲜竹沥的祛痰作用。结果:鲜竹沥50mL·kg-1

25mL·kg-1能延迟枸椽酸所致豚鼠的咳嗽潜伏期(P<0.001)

减少咳嗽次数(P<0.001)。鲜竹沥20mL·kg-1能延迟氨水所致小鼠的咳嗽潜伏期(P<0.05)

减少咳嗽次数(P<0.05)。鲜竹沥20mL·kg-1

10mL·kg-1能促进小鼠气管酚红分泌(P<0.05)

加速兔离体气管黏液纤毛运动(P<0.05)。结论:鲜竹沥具有明显的镇咳祛痰作用。

Abstract

Objective:To investigate the antitussive and expectorant effects of Succus bambusaes.Methods:Cough models were conducted by 17.5% citric acid-induced in guinea pig and 28% ammonia-induced in mouse to observe the antitussive efect of succus bambusae.Tracheal phenol red test in mouse and the in vitro tracheal mucociliary transport activity of rabbit trachea slice were used to investigate their expectorant effects.Results:Succus bambusaes of 50 mL·kg-1、25 mL·kg-1 could prolong the incubation period of cough and reduce the frequency of cough citric acid-induced in guinea pig(P<0.001)

and Succus bambusaes of 20 mL·kg-1 could prolong the incubation period of cough and reduce the frequency of cough ammonia-induced in mouse(P<0.05)

and succus bambusaes of 20 mL·kg-1、10 mL·kg-1 could obviously increase the tracheal excretion of phenol red(P<0.05) and speed up the tracheal mucociliary transport(P<0.05)

compared with that of the control group.Conclusion:Succus bambusaes has antitussive and expectorant effects.

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Related Institution

The First Hospital of Hebei Medical University

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