The Effect of Shen Shuai KeLi on Endothelin and Nitric Monoxide in Patients with Chronic Renal Failure

WANG Xiao-juan; LEI Ying; GUO Jian-sheng; GUO Xuan; HU Fang

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The Effect of Shen Shuai KeLi on Endothelin and Nitric Monoxide in Patients with Chronic Renal Failure

更新时间：2024-09-23

- The Effect of Shen Shuai KeLi on Endothelin and Nitric Monoxide in Patients with Chronic Renal Failure
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 13, Issue 1, Pages: 64-66(2007)
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- Published：2007
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WANG Xiao-juan, LEI Ying, GUO Jian-sheng, et al. The Effect of Shen Shuai KeLi on Endothelin and Nitric Monoxide in Patients with Chronic Renal Failure[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(1): 64-66.
DOI：

WANG Xiao-juan, LEI Ying, GUO Jian-sheng, et al. The Effect of Shen Shuai KeLi on Endothelin and Nitric Monoxide in Patients with Chronic Renal Failure[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(1): 64-66. DOI：

摘要

目的:观察肾衰颗粒对慢性肾功能衰竭患者的血浆内皮素(ET)、一氧化氮(NO)的影响及疗效。方法:60例慢性肾功能衰竭患者随机分为2组

治疗组30例口服肾衰颗粒

对照组30例口服包醛氧淀粉

观察2组血尿素氮(BUN)、血肌酐(SCr)、肌酐清除率(Ccr)、血浆内皮素(ET)、一氧化氮(NO)的变化。结果:治疗组BUN、Cr下降明显(P<0.01)

Ccr升高明显(P<0.01)

与阳性对照组比无差异;ET下降明显(P<0.01)

NO升高明显(P<0.01)

且均优于阳性对照组(P<0.05

P<0.01)。结论:肾衰颗粒能延缓慢性肾功能衰竭的进展。

Abstract

Objective:To observe the effect of Shen Shuai KeLi on endothelin(ET) and nitrogen monoxide(NO)of chronic renal failure(CRF).Method:60 patients with CRF were randomly divided into two groups.30 patients in treatment group were treated with ShenShuai KeLi;the other 30 patients in control group were treated with oxyamyli tectus aldehydum.The blood urea nitrogen(BUN)

serum creatinins(Scr)

ET and creatinine clearance rate(Ccr) were detected in both groups.Results:Compared with those in control group

the BUN

ET in treatment group decreased significantly(P<0.01)

and the NO

Ccr in treatment group increased significantly(P<0.01).Conclusion:ShenShuai KeLi can decrease the BUN

and Scr and increase NO and Ccr in patients with chronic renal failure

so it may delay the progress of chronic renal failure.

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Related Author

WANG Xiao-juan

LEI Ying

GUO Jian-sheng

GUO Xuan

HU Fang

ZHANG Yuanyuan

JIN Peipei

BIAN Dong

Related Institution

The First Affiliated Hospital,TCM University of Hunan

湖南中医药大学第一附属医院湖南长沙410007

The First Affiliated Hospital of Hebei University of Chinese Medicine/Hebei Provincial Hospital of Traditional Chinese Medicine

Graduate School， Hebei University of Chinese Medicine

Affiliated Hospital of Hebei University of Chinese Medicine/Hebei Provincial Hospital of Traditional Chinese Medicine

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