Objective:To review the advance on regulation of vascular endothelial growth factor(VEGF) in tumor tissue by natural drugs.Methods:The advance of domestic and abroad study on the aspect of single drug and compound recipe were analyzed.Results:Mass data about the study of anti-angiogenesis effect in tumor tissue by natural drugs has been assembled by domestic or abroad research institutes

and the principal target was focused on the regulation of VEGF.Conclusions:The research method and technology has been well developed

and the study of mechanism has been achieved.There are many differences in the methods and objects between domestic and abroad research.