Protective Effect of Leonurine on Acute Myocardial Ischemia Injury in Rats
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Protective Effect of Leonurine on Acute Myocardial Ischemia Injury in Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 13, Issue 2, Pages: 21-24(2007)
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Published:2007
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XIONG Ying, YANG Jie-ren. Protective Effect of Leonurine on Acute Myocardial Ischemia Injury in Rats[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(2): 21-24.
DOI:
XIONG Ying, YANG Jie-ren. Protective Effect of Leonurine on Acute Myocardial Ischemia Injury in Rats[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(2): 21-24.DOI:
Protective Effect of Leonurine on Acute Myocardial Ischemia Injury in Rats
Objective:To investigate the protective effect of leonurine(Leo) on pituitrin(Pit)-induced acute myocardial ischemia injury in rats.Methods:Pit was administrated intraperitoneally to induce acute myocardial ischemia injury in rats.The locomotion of J point(mv) and T wave(mv) in ECG was allowed to evaluate the degree of myocardial ischemia.The content of cardiac troponin T(cTnT) in serum and myocardium was measured by radio immunoassay.Results:In Leo(3
5
7
9 mg/kg) groups
the elevation of J point and T wave was lowered.The contents of cTnT in serum and myocardium were obviously decreased.Linear regression analysis(scatterplot) indicated that there is dose-effect relationship within certain dose range.Conclusions:Leo can inhibit Pit-induced myocardial ischemia injury