Comparative Study of Hepatoxicity Induced by Genipposide in SD Rat,Wistar Rat and ICR Mouse
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Comparative Study of Hepatoxicity Induced by Genipposide in SD Rat,Wistar Rat and ICR Mouse
Chinese Journal of Experimental Traditional Medical FormulaeVol. 13, Issue 4, Pages: 31-33(2007)
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Published:2007
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LI De-feng, CHENG Long, WU Hong-wei, et al. Comparative Study of Hepatoxicity Induced by Genipposide in SD Rat,Wistar Rat and ICR Mouse[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(4): 31-33.
DOI:
LI De-feng, CHENG Long, WU Hong-wei, et al. Comparative Study of Hepatoxicity Induced by Genipposide in SD Rat,Wistar Rat and ICR Mouse[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(4): 31-33.DOI:
Comparative Study of Hepatoxicity Induced by Genipposide in SD Rat,Wistar Rat and ICR Mouse
Objective:To compare the hepatotoxicity induced by geniposide SD rat
wistar rat and ICR mouse of different age.Methods:SD rats Wistar rats and ICR mice were given geniposide intragastically for 3 days
and then changes in appearance and body weight were observed;weight of livers was measured and the organ index was calculated;activities of serum ALT
AST and level of TBIL were determined.Results:Rats:The dosages of geniposide in 280 mg/kg could result in increasing livers weight
organ index
activities of ALT
AST and level of TBIL in serum.Mouse:The dosages of geniposide in 560 mg/kg did not induce obvious hepatotoxicity
the dosages of geniposide in(1 860) mg/kg couldincrease the activity of ALT and level of TBIL.Conclusions:There is no obvious difference in hepatotoxicity induced by geniposide to SD rat and Wistar rat of different age.Geniposide shows no obvious hepatotoxicity to mouse.
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Sichuan Academy of Chinese Medicine Sciences, Sichuan Institute for Translational Chinese Medicine, State Key Laboratory of Quality Evaluation of Traditional Chinese Medicine(TCM),Sichuan Geoherbs System Engineering Technology Research Center,Sichuan Provincial Key Laboratory of Quality Evaluation of TCM and Innovative Chinese Medicine Research
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