Combination of Saponins of Glycyrrhiza Uralensis Fisch(GS) and Platycodon grandiflorum A.DC(PS) for Duration of Effect

LIU Bin; Qi Yun; SONG Yang; CAI Run-lan; Wang Min; XIE Chen; LUO Xiu-zhen

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Combination of Saponins of Glycyrrhiza Uralensis Fisch(GS) and Platycodon grandiflorum A.DC(PS) for Duration of Effect

更新时间：2024-01-04

- Combination of Saponins of Glycyrrhiza Uralensis Fisch(GS) and Platycodon grandiflorum A.DC(PS) for Duration of Effect
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 13, Issue 4, Pages: 28-31(2007)
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- Published：2007
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LIU Bin, Qi Yun, SONG Yang, et al. Combination of Saponins of Glycyrrhiza Uralensis Fisch(GS) and Platycodon grandiflorum A.DC(PS) for Duration of Effect[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(4): 28-31.
DOI：

LIU Bin, Qi Yun, SONG Yang, et al. Combination of Saponins of Glycyrrhiza Uralensis Fisch(GS) and Platycodon grandiflorum A.DC(PS) for Duration of Effect[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(4): 28-31. DOI：

摘要

目的:考查甘草皂苷与桔梗皂苷祛痰和抗炎作用的时间协同。方法:采用气管酚红排泌、二甲苯致耳肿胀及PLA2致足跖肿胀模型

考查两者合用对药效持续时间的影响

以及运用金氏Q值法对两者合用的相互作用性质进行定量评价。结果:甘草皂苷与桔梗皂苷合用可明显延长药效持续时间

Q值法评价显示出不同结果

随着时间延长

在气管酚红排泌模型中

由相加转为协同;在二甲苯致耳肿胀模型中

单用无效合用有效的时间点下

表现为相加和协同;在PLA2致足跖肿胀模型中

则表现为相加和拮抗。结论:甘草皂苷与桔梗皂苷合用在祛痰与抗炎方面具备时间协同特点

协同性质与两药配比、剂量有关。

Abstract

Objective:To evaluate the combination of saponins of Glycyrrhiza uralensis Fisch(GS) and Platycodon grandiflorum A.DC(PS) for duration of expectorant and anti-inflammatory effects.Methods:The duration of effects was observed directly in phenol drain model

xylene-induced mouse ear edema model and PLA2-induced mouse paw edema model

and the combinative effects of two agents was evaluated quantitatively by Jin's Q formula.Results:Co-administration of GS and PS in 8∶1 can extend the duration of expectorant and anti-inflammatory effects

when compared to any agent alone.By the method of Jin's Q formula

additivity

synergism or antagonism was obtained in different models.Conclusions:GS and PS combined have characteristic of synergism in duration of expectorant and anti-inflammatory effects.The combinative ratio and total dose are two factors that can affect the combinative effects.

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Related Institution

College of Traditional Chinese medicine

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