Effect of Buyang Huanwu Decoction and Its Alkaloid and Glycoside on Anticoagulative System Arterial Thrombosis Rat

TANG Ying-hong1; LIANG Yan2; ZHANG Shu-ping2; YANG Jing2; DENG Bingxiang2; DENG Chang-qing2

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Effect of Buyang Huanwu Decoction and Its Alkaloid and Glycoside on Anticoagulative System Arterial Thrombosis Rat

更新时间：2024-01-04

- Effect of Buyang Huanwu Decoction and Its Alkaloid and Glycoside on Anticoagulative System Arterial Thrombosis Rat
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 13, Issue 6, Pages: 39-42(2007)
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- Published：2007
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TANG Ying-hong1, LIANG Yan2, ZHANG Shu-ping2, et al. Effect of Buyang Huanwu Decoction and Its Alkaloid and Glycoside on Anticoagulative System Arterial Thrombosis Rat[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(6): 39-42.
DOI：

TANG Ying-hong1, LIANG Yan2, ZHANG Shu-ping2, et al. Effect of Buyang Huanwu Decoction and Its Alkaloid and Glycoside on Anticoagulative System Arterial Thrombosis Rat[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(6): 39-42. DOI：

摘要

目的:研究补阳还五汤及其生物碱、苷两类有效组分对FeCl3所致大鼠颈总动脉血栓形成后抗凝血酶Ⅲ(AT-Ⅲ)和蛋白C(PC)活性的影响。方法:大鼠给药后以35% FeCl3诱导颈总动脉血栓形成

以发色底物法测定血浆AT-Ⅲ和PC活性。结果:FeCl3可诱导颈总动脉血栓形成。补阳还五汤及其有效组分生物碱、苷可使颈总动脉血栓重量减轻(P<0.05)。模型组AT-Ⅲ活性低于假手术组(P<0.01);与模型组比较

生物碱组和补阳还五汤原方组AT-Ⅲ活性均显著降低(P<0.01)

而苷组与模型组比较差异无显著性意义(P>0.05)。模型组PC活性与假手术组比较有所降低(0.10>P>0.05);与模型组比较

生物碱组PC活性显著降低(P<0.05)

而苷组和原方组PC活性与模型组比较则显著性升高(P<0.01)

且苷和原方组PC活性高于假手术组(P<0.01)。结论:补阳还五汤、生物碱和苷可抑制血栓形成。补阳还五汤原方既可能通过与AT-Ⅲ结合而发挥抗凝作用

又可防止血栓形成后血浆中PC的消耗。其有效组分生物碱既可能通过与AT-Ⅲ结合而灭活凝血因子

又可能促进了PC对凝血因子的灭活

从而发挥抗凝作用。苷的抗血栓可能不是通过AT-Ⅲ和PC介导的。

Abstract

Objective:To investigate effect of Buyang Huanwu Decoction(BHD) and its active fractions such as alkaloid and glycoside on activities of antithrombin Ⅲ(AT-Ⅲ) and protein C(PC) after carotid arterial thrombosis induced by ferric chloride in rats. Methods: Rats were administered with tested drugs and then left carotid artery was applied with FeCl3 to form thrombus.The activities of antithrombin Ⅲ(AT-Ⅲ) and protein C(PC) in plasma in rats were determined by chromogenic substrate assay.Results:BHD

alkaloid and glycoside could decrease thrombotic weight (P<0.05).The activities of AT-Ⅲ in the model group were significantly lower than those of the sham-operated group(P<0.01).The activities of ATⅢ in BHD and alkaloid group were markedly lower than those of the model group(P<0.01)

No significant difference was found in activities of AT-Ⅲ between the glycoside and model group(P>0.05).The activities of PC in the model group were slightly lower than those of the sham-operated group(0.10>PP>0.05).Compared with the model group

the activities of PC in alkaloid group were decreased(P<0.05).But the activities of PC in BHD and glycoside group were increased when compared to the model group(P<0.01) and sham group(P<0.01).Conclusions: BHD

alkaloid and glycoside could inhibit thrombosis. Antithrombotic actions of BHD may be related to binding with AT-Ⅲ

and it could also prevent the consumption of PC after carotid arterial thrombosis.Antithrombotic action of alkaloid may concerne inactivating coagulation factors by binding with AT-Ⅲ or accelerating inactivation of coagulation factors by PC.Antithrombotic action of glycoside may not be related to AT-Ⅲ and PC.

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