Effects of Jincao Tablet on Expression of Nitric Oxide Synthase in the Model of Uterine Leiomyoma in Rat

LI Jian-rong1; 2; WU Lan-sheng1; ZHANG Guang-ping1; TONG Yan1; WANG Jin-yu1

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Effects of Jincao Tablet on Expression of Nitric Oxide Synthase in the Model of Uterine Leiomyoma in Rat

更新时间：2024-01-04

- Effects of Jincao Tablet on Expression of Nitric Oxide Synthase in the Model of Uterine Leiomyoma in Rat
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 13, Issue 5, Pages: 40-42(2007)
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- Published：2007
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LI Jian-rong1, 2, WU Lan-sheng1, et al. Effects of Jincao Tablet on Expression of Nitric Oxide Synthase in the Model of Uterine Leiomyoma in Rat[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(5): 40-42.
DOI：

LI Jian-rong1, 2, WU Lan-sheng1, et al. Effects of Jincao Tablet on Expression of Nitric Oxide Synthase in the Model of Uterine Leiomyoma in Rat[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(5): 40-42. DOI：

摘要

目的:探讨金草片对子宫肌瘤模型大鼠子宫组织一氧化氮合酶(NOS)表达的影响

及该模型与临床发病机理的相关性。方法:以雌激素和雌、孕激素肌肉注射造成大鼠子宫肌瘤模型

测定子宫组织的总型NOS和诱导型NOS(iNOS)的水平;用放射配体结合分析法测定子宫组织雌激素受体(ER)水平;用放射免疫法测定血清雌二醇(E2)和孕酮(P)水平。结果:模型组大鼠子宫组织总型NOS和诱导型iNOS表达均明显增强

E2、ER和P水平升高;P水平与NOS表达相关

与iNOS表达不直接相关。金草片组可明显降低子宫组织NOSi、NOS和ER表达

降低血清E2和P水平

与模型组比较差异显著。结论:金草片可抑制子宫肌瘤模型大鼠子宫组织NOS表达

其作用可能是该品种治疗子宫肌瘤的作用机理之一。

Abstract

Objective:To investigate effects of Jincao tablet on expression of nitric oxide synthase in the model of uterine leiomyoma in rat and the relationship between the model and pathogenesis.Method:Rats were injected with diethyl stilbestrol and progesterone respectively.The expression of NOS and iNOS in uterine leiomyoma tissue were measured by kit;the levels of ER in uterine leiomyoma tissue was assayed by radioligand combination assay;the levels of E2 and P in serum was determined by radioimmunity.Result:Compared with normal group

the levels of and NOS

iNOS

E2 and P of model group were significantly decreased.The levels of P were related to NOS and were not related to iNOS.Jincao tablet group was obviously different from model group.Conclusion:Jincao tablet could improved the levels of immune function of the model of uterine leiomyoma in rat

and it might be played a role in the pathogenesis of leiomyoma.

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Related Author

SUN Wen-yan

ZHANG Shuo-feng

SUN Jian-ning

WANG Bin

SU Yun-ming2

ZHENG Shu-guo1

WANG Hong-ting1

WANG Di-sheng2

Related Institution

Department of Pharmacology,Guiyang Medical College

Depatment of Pharmacology,Beijing University of Chinese Medicine

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