Effects of Houshiheisan on Nerve Growth Factor Expression after Focal Cerebral Ischemia Reperfusion Injury in Rats

ZHAO Hui; ZHANG Qiu-xia; MU Yang

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Effects of Houshiheisan on Nerve Growth Factor Expression after Focal Cerebral Ischemia Reperfusion Injury in Rats

更新时间：2024-01-04

- Effects of Houshiheisan on Nerve Growth Factor Expression after Focal Cerebral Ischemia Reperfusion Injury in Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 12, Issue 11, Pages: 43-46(2006)
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- Published：2006
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ZHAO Hui, ZHANG Qiu-xia, MU Yang. Effects of Houshiheisan on Nerve Growth Factor Expression after Focal Cerebral Ischemia Reperfusion Injury in Rats[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(11): 43-46.
DOI：

ZHAO Hui, ZHANG Qiu-xia, MU Yang. Effects of Houshiheisan on Nerve Growth Factor Expression after Focal Cerebral Ischemia Reperfusion Injury in Rats[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(11): 43-46. DOI：

摘要

目的:研究侯氏黑散对大鼠脑缺血再灌注损伤脑组织神经生长因子(NGF)表达的影响。方法:栓线法阻断大脑中动脉建立大鼠局灶性脑缺血再灌注损伤模型

术后观察动物神经行为学变化并进行神经病学评分

采用免疫组化与医学图像分析相结合的方法检测假手术组、模型组、侯氏黑散各组大鼠缺血脑组织NGF的表达。结果:与模型组缺血侧比较

侯氏黑散组大鼠神经功能缺损得到改善

皮质及海马区NGF的阳性细胞数及面积光密度值比模型组明显增加(P<0.05)。结论:侯氏黑散可上调脑缺血再灌注后缺血脑组织内源性NGF的表达

而起到脑保护作用。

Abstract

Objective:To study the effect of Houshiheisan on the expression of nerve growth factor(NGF) after focal cerebral ischemia reperfusion injury in rats.Methods: Rat cerebral ischemia reperfusion injury model was produced by occlusion of the right middle cerebral artery.Using behavioral test

evaluate the neurological deficiency of each group after operation.Immunohistochemistry method was performed to observe the NGF expression as well as the effect of Houshiheisan on them.Results: Houshiheisan significantly improved the neurological deficits

In the ischemic side of the model group

the number of NGF positive cells were lower as compared with those in the sham-operated side of the sham-operated groug(P<0.05).The number of NGF positive cells in the Houshiheisan group were more than that of model group(P<0.05)

similar to that of sham-operated groug.Conclusion: The results indicate Houshiheisan can improve the expression of NGF after cerebral ischemia.It may be one of mechanisms for the treatment of ischemic stroke.

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