The Effect of Coadministration with on Cytochrome P450 in Rat Liver
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The Effect of Coadministration with on Cytochrome P450 in Rat Liver
Chinese Journal of Experimental Traditional Medical FormulaeVol. 12, Issue 12, Pages: 48-50(2006)
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Published:2006
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XIAO Cheng-rong, WANG Yu-guang, DAI Fang-guo, et al. The Effect of Coadministration with on Cytochrome P450 in Rat Liver[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(12): 48-50.
DOI:
XIAO Cheng-rong, WANG Yu-guang, DAI Fang-guo, et al. The Effect of Coadministration with on Cytochrome P450 in Rat Liver[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(12): 48-50.DOI:
The Effect of Coadministration with on Cytochrome P450 in Rat Liver
Objective:To elucidate the imcompatible mechanism of traditional Chinese Medicine
the effect of Aconitum coadministration with Lilac Daphne on the main enzyme activity
such as CYP1A2
CYP2E1 and CYP3A1/2.Methods:CYP1A2 and CYP2E1 activities were quantitated by high performance liquid chromatographic(HPLC) assay;CYP3A1/2 activity was quantitated by UV chromatography.Results:Aconitum coadministration with Lilac Daphne obviously promoted the activities of CYP1A2
CYP2E1 and CYP3A1/2(P<0.05~0.001).Conclusion:The effect on the enzymes activity of CYP1A2、CYP2E1、CYP3A1/2 of Aconitum coadministration with Lilac Daphne may change the toxic component's metabolism and influence phamarceutical effect and toxicity.The herb-herb interaction maybe occur.
Modulation Effects of Water Extract from and on the Activity and mRNA Expression of Cytochrome P450 Isoenzymes in Rat Liver
Preparation of Baoyuan Chewable Tablets and Evaluation of Its Anti-fatigue Effect
Mechanism of Glycyrrhizae Radix et Rhizoma Alleviating Tripterygium wilfordii Polyglycoside Tablets-induced Liver Injury
Effect of Aidi Injection on Expression of Cytochrome P450 Enzyme in DEN-induced Hepatocellular Carcinoma Rats
Effect of Different Combinations of Arbuscular Mycorrhiza on Paris polyphylla var. yunnanensis and Chemical Components
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