Objective:To study the best preparation process for Yifuning soft capsule.Methods:Taking pharmacodynamics results as the evaluation indexes to screening effective ingredients extracted from Rhizoma Curcumae

it was shown that oleum curcumae wenchowensis was the active situs;the SFE-CO2 extraction process of oleum curcumae wenchowensis were optimized by orthogonal design;subambient temperature technology was used to porphyrization Oviductus Ranae;the forming preparation parameters of soft elastic capsules

such as quantity of absorbing substance

suspending agent and minim were also determined.Results:The optimum preparation process of Yifuning soft capsule was following:the best extraction process of extracting Rhizoma Curcumae was 2.5 h

the temperature was 45℃ and the pressure was 22 MPa;the best porphyrization parameters were crashing Oviductus Ranae 20 min under the temperature -20℃.Conclusions:It was proved that this preparation process was reasonable and feasible.