The Effect of Ejiao on Airway Inflammation and Th1/Th2 Cytokines in Serum Of Asthmatic Rats
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The Effect of Ejiao on Airway Inflammation and Th1/Th2 Cytokines in Serum Of Asthmatic Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 12, Issue 6, Pages: 59-61(2006)
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Published:2006
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ZHAO Fu-dong, DONG Jing-cheng, CUI Yan, et al. The Effect of Ejiao on Airway Inflammation and Th1/Th2 Cytokines in Serum Of Asthmatic Rats[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(6): 59-61.
DOI:
ZHAO Fu-dong, DONG Jing-cheng, CUI Yan, et al. The Effect of Ejiao on Airway Inflammation and Th1/Th2 Cytokines in Serum Of Asthmatic Rats[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(6): 59-61.DOI:
The Effect of Ejiao on Airway Inflammation and Th1/Th2 Cytokines in Serum Of Asthmatic Rats
Objective:To study the effects of Ejiao on Th1/Th2 cytokines and the mechanism of which preventing and curing bronchial asthma.Methods:60 wistar rats were randomly divided into 6 groups.Group A was normal group which were administered with NS.Group B
C and D were administered with low
moderate and high dose Ejiao.Group E were administered with Polysaceharidc.Group F were asthma group.1L-4 and IFN-γ in serum were detected by enzyme-linked immunosorbent assay(ELISA).Results:Compared with normal group
the concentration of IFN-γ in group F was decreased significantly.compared with asthma group
the concentration of IL-4 of low and moderate dose Ejiao groups and Polysaceharidc group were decreased significantly(P<0.05)
and there was less eosinophils in the lungs of group A、B、C、E than that in group F.Conclusion:Ejiao could regulate the ratio of Th1/Th2 by decreasing Th2 subset instead of increasing Th1 subset.On the other hand
it could inhibit eosinophils to move from peripheral blood to the lungs of asthma rats.