Protective Effect of Stachydrine on Myocardial Ischemia-Reperfusion Injury in Rats

MA Yu-hong; YANG Jie-ren

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Protective Effect of Stachydrine on Myocardial Ischemia-Reperfusion Injury in Rats

更新时间：2024-01-04

- Protective Effect of Stachydrine on Myocardial Ischemia-Reperfusion Injury in Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 12, Issue 5, Pages: 40-42(2006)
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- Published：2006
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MA Yu-hong, YANG Jie-ren. Protective Effect of Stachydrine on Myocardial Ischemia-Reperfusion Injury in Rats[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(5): 40-42.
DOI：

MA Yu-hong, YANG Jie-ren. Protective Effect of Stachydrine on Myocardial Ischemia-Reperfusion Injury in Rats[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(5): 40-42. DOI：

摘要

目的:研究水苏碱对大鼠急性心肌缺血再灌注损伤的保护作用。方法:冠脉结扎法复制大鼠急性心肌缺血再灌注模型。测定给药后145min血清和心肌组织中乳酸脱氢酶(LDH)、肌酸激酶(CK)、肌钙蛋白(cTnT)、超氧化物歧化酶(SOD)、丙二醛(MDA)和一氧化氮(NO)。结果:水苏碱(3、6、12mg/kg

iv)可降低缺血再灌注损伤时LDH、CK活性和cTnT浓度

减少MDA含量

升高SOD活性及NO水平。结论:水苏碱对大鼠急性心肌缺血再灌注损伤具有保护作用。

Abstract

Objective:To study the protective effect of stachydrine on myocardial ischemia-reperfusion injury in rats.Methods:Myocardial ischemia-reperfusion injury model was made by ligating the coronary artery for 30min followed by reperfusion for 120min in anesthetized rats.All animals were given the stachydrine or normal saline

danshen after ligation.LDH and CK and SOD activity

MDA content

NO level in serum and in myocardial homogenate and cTnT content in serum were measured.Results:The results showed that stachydrine(3

12mg/kg

iv)could inhibit the activity of LDH and CK and cTnT(P<0.05 or P<0.01)

decrease MDA content(P<0.01)

and increase the SOD activity and NO level(P<0.05 or P<0.01) in comparison with model group.Conclusion:Stachydrine can protect the effect of myocardial ischemia-reperfusion injury in rats.

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