Effects and Mechanism of Dawei Capsule on Negative Symptoms in Schizophrenia Model Mice

CUI Jie-feng1; 2; SONG Chong-shun1; REN Ying1; YIN Jun-xiang1; Guo Jing1; SUN Hai-yun1; YANG Jin-duo1

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Effects and Mechanism of Dawei Capsule on Negative Symptoms in Schizophrenia Model Mice

更新时间：2024-01-04

- Effects and Mechanism of Dawei Capsule on Negative Symptoms in Schizophrenia Model Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 12, Issue 3, Pages: 41-43(2006)
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- Published：2006
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CUI Jie-feng1, 2, SONG Chong-shun1, et al. Effects and Mechanism of Dawei Capsule on Negative Symptoms in Schizophrenia Model Mice[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(3): 41-43.
DOI：

CUI Jie-feng1, 2, SONG Chong-shun1, et al. Effects and Mechanism of Dawei Capsule on Negative Symptoms in Schizophrenia Model Mice[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(3): 41-43. DOI：

摘要

目的:研究达维胶囊(达维)对精神分裂症阴性症状模型小鼠的治疗作用及相关机理。方法:注射低于麻醉剂量的氯胺酮(30mg/kg)

制作精神分裂症阴性症状动物模型

用强迫游泳法测定各组小鼠在游泳时保持不动时间

评价达维胶囊对精神分裂症阴性症状小鼠的治疗效果。并用荧光分光光度法测定小鼠全脑内及血清中神经递质(DA

5-HT)含量

探讨其作用机制。结果:与模型组相比

达维大、中剂量组及氯氮平组能使小鼠强迫游泳保持不动时间明显缩短

脑内及血中5-HT含量明显降低

血中NE水平明显升高。结论:达维胶囊对精神分裂症的阴性症状小鼠有一定的治疗作用

其作用机理可能与其能调节脑内5-HT和NE能神经系统功能有关。

Abstract

Objective:To observe therapeutic effect and mechanism of negative symptoms in schizophrenia model mice by DaWei Capsule.Methods:Negative symptoms of schizophrenia model were developed by subanesthetic-dose(30mg/kg)Ketamine-induced enhancement of immobility time of forced swimming

and shorten immobility time of forced swimming was observed.Moreover

the levels of neurotransmitter in mice brains (DA

5-HT)were measured by fluorospectrophotometry in order to explore the action mechanisms.Results:Compared with model group

DaWei Capsule with large

medium

and small dose

and clozapine can significantly shorten immobility time of forced swimming in mice

and content of 5-HT in brain and serum decreased and level of NE in serum increased in DaWei Capsule group.Conclusion:DaWei capsule and clozapine have effect on the treatment of negative symptoms in schizophrenia

action mechanism of which may be involved in 5-HT and NE system in brain.

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