Studies on the Absorption Kinetics of Paeonol in Rat's Intestines
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Studies on the Absorption Kinetics of Paeonol in Rat's Intestines
Chinese Journal of Experimental Traditional Medical FormulaeVol. 12, Issue 7, Pages: 35-37(2006)
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Published:2006
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TANG Ji-hui1, HU Rong-feng1, CHANG Gong2. Studies on the Absorption Kinetics of Paeonol in Rat's Intestines[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(7): 35-37.
DOI:
TANG Ji-hui1, HU Rong-feng1, CHANG Gong2. Studies on the Absorption Kinetics of Paeonol in Rat's Intestines[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(7): 35-37.DOI:
Studies on the Absorption Kinetics of Paeonol in Rat's Intestines
Objective:To explore the absorption mechanism of Paeonol from various intestinal segments and offer biophamaceutics data for Paeonol new dosage form.Method:The absorption kinetics and permeability rate constants were investigated by the in situ perfusing method in rats.Result:The absorption rate in rats was descend as the order of jejunum、ileum、duodenum and colon.The absorption of the drug conforms to the first-order kinetics and passive transport machanism.Conclusion:The results indicate that Paeonol can be formulated and prepared as sustained release dosage form.
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Related Author
TANG Ji-hui~1
HU Rong-feng~
常宫
ZHANG Wei
LI Ling-jun
WANG Ying-lan
ZHANG Wei
LI Ling-jun
Related Institution
1*),CHANG Gong~2
安徽省现代中药研究中心
Shandong University of Traditional Chinese Medicine,Ji’nan
Geriatric Care and Health Laboratory,Anhui University of Chinese Medicine
School of Integrated Chinese and Western Medicine,Anhui University of Chinese Medicine