Objective:To investigate the effect of different ratio of Huangqi Decoction(3∶1

6∶1

9∶1) on cholestatic cirrhosis in rats.Method:Rat cholestatic cirrhosis was duplicated by ligation of bile duct.After 1 week rats were divided into model control group and different ration of Huangqi Decoction groups.The oral administration of Huangqi Decoction lasted for 4 weeks

and then rats were sacrificed for determination of liver function

liver tissue Hyp conten and histological changes.Results:cholestatic cirrhosis was successfully duplicated after 5 weeks modeling.Compared with that of normal group

serum GGT and ALP activity

serum TBiL content and liver tissue Hyp content in model group increased significantlly(P<0.05～0.01 vs sham)

while serum TP and Alb content decreased significantly.Compared with that of model group

degree of cirrhosis in groups of ratio 3∶1 and 6∶1 of Huangqi Decoction alleviated significantly

serum ALP and GGT activity

serum TBiL content and liver tissue Hyp content decreased significantly(P<0.05～0.01 vs 5W model).Conclusion:The ratio of 3∶1 and 6∶1 of Huangqi Decoction inhibits formation of cholestatic cirrhosis effectively.