Research of  L.on Hyperlipidemia and Atherosclerosis in Quails

Zhou Fang; LI Ai-yuan; XIE Jin-xian; YANG Xiu-fen

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Research of L.on Hyperlipidemia and Atherosclerosis in Quails

更新时间：2024-01-04

- Research of L.on Hyperlipidemia and Atherosclerosis in Quails
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 12, Issue 8, Pages: 48-49(2006)
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- Published：2006
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Zhou Fang, LI Ai-yuan, XIE Jin-xian, et al. Research of L.on Hyperlipidemia and Atherosclerosis in Quails[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(8): 48-49.
DOI：

Zhou Fang, LI Ai-yuan, XIE Jin-xian, et al. Research of L.on Hyperlipidemia and Atherosclerosis in Quails[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(8): 48-49. DOI：

摘要

目的:观察蒲黄对鹌鹑高脂血症、动脉粥样硬化(AS)的作用。方法:实验采用喂高脂饲料(基本饲料85%、猪油14%、胆固醇1%)复制高血脂动物模型。蒲黄粉高、中、低剂量按4.0、2.0、1.0g/kg3个剂量灌胃给药

每天一次

连续8周

同时喂高脂饲料

第4周、8周分别测定总胆固醇(TC)、甘油三酯(TG)、内皮素(ET)、一氧化氮(NO)一次。结果:第4周测定TC、TG值

高、中、低剂量组与模型组比较差异有显著性意义(P<0.05)。第8周测定TC、TG

高、中、低剂量组与模型组比较均有明显的降低作用(P<0.01)

但对ET、NO差异无显著意义。对鹌鹑AS有一定抑制作用(P<0.01)。结论:蒲黄粉有较好的降血脂作用、抗动脉粥样硬化作用。

Abstract

Objective:To observe the influence of Typha angustifolia L.on hyperlipidemia

atherosclerosis(AS).Methods:The atherosclerotic quails's model was established by feeding fat food(basic food 85%

lard 14%

Cholestrol 1%).Low-dose group

mid-dose group and high-dose group of Typha angustifolia L.were 4g

1g·kg(-1)·d(-1) ig.respectively and to be continued eight weeks

and feed fat food at the same time.Total cholesterol(TC)

triglyceride(TG)

endothelin(ET)

nitric oxide(NO)

determined after four weeks and eight weeks.Result:The value of TC

TG showed significantly difference(P<0.05) by high-dose

mid-dose

low-dose comparing with model group at the 4th week.The value of TC

TG showed significantly lowering total cholesterol(P<0.01) by high-dose

mid-dose

low-dose comparing with model group at the 8th week.However ET and NO didn't show significant difference.Conclusion:Typha angustifolial L.can lower blood lipid and inhitit AS to some degree.

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Related Institution

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences

安徽中医学院第一附属医院安徽合肥230031

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