Effect of Guizhi Tang on the PKA and PKC Activities of Hypothalamus in Hypothermia Rats

ZHOU Jun1; 2; Li Cang-hai1; HUO Hai-ru1; LI Lan-fang1; KANG Xu-liang1; JIANG Nan1; JIANG Ting-liang1

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Effect of Guizhi Tang on the PKA and PKC Activities of Hypothalamus in Hypothermia Rats

更新时间：2024-01-04

- Effect of Guizhi Tang on the PKA and PKC Activities of Hypothalamus in Hypothermia Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 12, Issue 1, Pages: 20-22(2006)
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- Published：2006
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ZHOU Jun1, 2, Li Cang-hai1, et al. Effect of Guizhi Tang on the PKA and PKC Activities of Hypothalamus in Hypothermia Rats[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(1): 20-22.
DOI：

ZHOU Jun1, 2, Li Cang-hai1, et al. Effect of Guizhi Tang on the PKA and PKC Activities of Hypothalamus in Hypothermia Rats[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(1): 20-22. DOI：

摘要

目的:研究低体温大鼠下丘脑蛋白激酶A(PKA)、蛋白激酶C(PKC)活性的变化及桂枝汤的升温作用机理。方法:选用腹腔注射氨基比林低体温大鼠模型

先观测桂枝汤(p.o.)对模型大鼠体温的影响

继而采用放射性同位素法

测定给予桂枝汤后低体温大鼠下丘脑组织中PKA、PKC的活性。结果:桂枝汤可使低体温模型大鼠下丘脑组织中受抑的PKA、PKC活性显著增强

促进体温恢复。结论:PKA、PKC参与了大鼠的低体温过程

桂枝汤的升高体温的作用可能与提高下丘脑组织中PKA、PKC活性有关。

Abstract

Objective:To observe the changes of the activity of protein kinase A(PKA) and C(PKC)

and further investigate the mechanisms of anti-hypothermia action of Guizhi Tang.Methods:The hypothermia rats induced by i.p.aminopyrine were used to observe the action of Guizhi Tang on the body temperature and to detect the PKA and PKC activity in hypothalamus in model and Guizhi Tang-treated groups using isotopic tracing assay.Results:The drop of body temperature in rats induced by aminopyrine was counteracted and the PKA and PKC activities increased significantly after oral administration of Guizhi Tang.Conclusions:Both PKA and PKC may participate in the mechanism of hypothermia induction and the increases of PKA and PKC may contribute to the anti-hypothermia action of Guizhi Tang.

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Related Author

LI Cang-hai

Zhou Jun

Huo Hai-ru

LI Lan-fang

JIANG Ting-liang

GUO Shu-ying

Qi Yun

GUO Jian-you1

Related Institution

Hubei Shizhen Laboratory

Engineering Research Center of Traditional Chinese Medicine Protection Technology and New Product Development for the Elderly Brain Health， Ministry of Education， Hubei University of Chinese Medicine

Key Laboratory of Chinese Medicine Resource and Compound Prescription， Ministry of Education， Hubei University of Chinese Medicine

Key Laboratory of TCM Viscera Theory and Application， Ministry of Education， Liaoning University of TCM

Innovation Engineering Technology Center of Chinese Medicine， Liaoning University of TCM

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