Objective:To study the effect of Xinshuaining Pill on chronic heart failure of dogs.Methods:The chronic heart failure model was induced by ligating abdominal aorta of dogs.The changes of their heart function and ardiac muscle pathologic index were observed after taking Xinshuaining Pill in the dosage of 0.3g·kg -1

0.6g·kg -1

1.2g·kg -1 per day

respectively.Results:The middle and high dosage of the Xinshuaining Pill can not only increase the cardiac output

cardiac output index

stroke volume

stroke volume index and left ventricular-stroke work index

but also decrease the pulmonary capillary wedge pressure

systemic vascular resistance

left ventricular end-diastolic pressure.The two dosages can also improve the level of myocardial hypertrophy and decrease the index of heart weight.Apparente endocardium thickening and mucinous degeneration

adipose degeneration of some cardiac muscle cells

hyperplasia of focal and lattice fibers tissue in ardiac muscle stroma and formation of irregular lamellar fiber scar of model group can be seen under optical microscope.Compared with model group

endocardium and ardiac muscle stroma pathological changes of middle and high dosages of the Xinshuaining Pill groups were obviously lessened.Conclusion:Xinshuaining Pill can improve the systole and diastole function in chronic heart failure model of dogs.