Cognition Enhancing Effect of Liuwei Dihuang Pill on Deterioration of Learning and Memory induced by D-Galactose in Rats
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Cognition Enhancing Effect of Liuwei Dihuang Pill on Deterioration of Learning and Memory induced by D-Galactose in Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 12, Issue 8, Pages: 44-46(2006)
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Published:2006
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ZHU Kun-jie1, 2, SUN Jian-ning1. Cognition Enhancing Effect of Liuwei Dihuang Pill on Deterioration of Learning and Memory induced by D-Galactose in Rats[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(8): 44-46.
DOI:
ZHU Kun-jie1, 2, SUN Jian-ning1. Cognition Enhancing Effect of Liuwei Dihuang Pill on Deterioration of Learning and Memory induced by D-Galactose in Rats[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(8): 44-46.DOI:
Cognition Enhancing Effect of Liuwei Dihuang Pill on Deterioration of Learning and Memory induced by D-Galactose in Rats
Objective:To probe the cognition enhancing effect of Liuwei Dihuang pill on deterioration of learning and memory induced by D-galactose(D-gal)in rats
and to study the mechanism.Methods:Sub-acute aged animal model was replicated by administration of 75 mg·kg-1·d-1 s.c.for 8 weeks.Meanwhile
treating with different dose of Liuwei Dihuang pill for 8 weeks.The learning and memory ability was observed by Morris water maze.Activities of mono amine oxidase(MAO) and acety lcholinesterase(AchE) in brain tissue were detected.Results:High and low dose Liuwei Dihuang pill can enhance learning and memory ability.It can also decrease activities of mono amine oxidase(MAO) and acetylcholinesterase(AchE) in brain tissue.Conclusions:Liuwei Dihuang pill can improve the deterioration of learning and memory induced by D-gal in rats.The possible mechanism are regulating of central cholinergic nerve system and noradrenergic nerve system.
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