Optimization of Formulation of Ginkgobiloba Immediate Release Tablet

HU Rong-feng1; 2; ZHU Jia-bi1; PENG Dai-yin2; TANG Ji-hui2

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Optimization of Formulation of Ginkgobiloba Immediate Release Tablet

更新时间：2024-01-04

- Optimization of Formulation of Ginkgobiloba Immediate Release Tablet
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 12, Issue 2, Pages: 7-10(2006)
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- Published：2006
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HU Rong-feng1, 2, ZHU Jia-bi1, et al. Optimization of Formulation of Ginkgobiloba Immediate Release Tablet[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(2): 7-10.
DOI：

HU Rong-feng1, 2, ZHU Jia-bi1, et al. Optimization of Formulation of Ginkgobiloba Immediate Release Tablet[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(2): 7-10. DOI：

摘要

目的:优化银杏叶分散片处方

制备中药口服固体速释制剂。方法:以颗粒的流动性、片剂的崩解时间、片剂的硬度和片剂中有效成分的溶出速度为指标

采用正交设计综合评分法优化干法制粒制备银杏叶分散片的处方和制备工艺。结果:优化所得处方为微晶纤维素40%

羧甲基淀粉钠10%

糊精约15%。以此处方制备的银杏叶分散片在崩解时间不超过3min

硬度为4.9KG

有效成分的溶出速度参数T50为3.4min。结论:优化所得处方合理稳定

银杏叶分散片具有明显的速释特征。

Abstract

Objective:To optimize the formulation of the Ginkgobiloba immediate release tablet.Method:The immediate release tablet was prepared by using dry granules.The formulation and preparation technology was optimized by using orthogonal design which took the flow property of granules

the hardness

the disintegrating time and the dissolution rate of the tablet as indices.Result:The optimized formulation contained 40% microcrystalline cellulose

10% sodium carboxymethyl starch and 15% dextrin.The hardness

the disintegrating time and T50 of the tablet were 4.9KG

3min and 3.4min respectively.Conclusion: It is successful to prepare immediate release tablet.The optimized formulation is rational and stable

the tablet could be released quickly.

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