The Influence of YUEHUA Capsule(YHC) on T Ly Mphocyte Subgroups and Cytokines in Rats with Multi-drug Resistant Tuberculosis(MDR-TB)

OUYANG Jian-jun 1; WU Can-rong1; CHEN Bei-yang1; BAI Yu-qian2; ZENG Jiao-fei1

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The Influence of YUEHUA Capsule(YHC) on T Ly Mphocyte Subgroups and Cytokines in Rats with Multi-drug Resistant Tuberculosis(MDR-TB)

更新时间：2024-01-04

- The Influence of YUEHUA Capsule(YHC) on T Ly Mphocyte Subgroups and Cytokines in Rats with Multi-drug Resistant Tuberculosis(MDR-TB)
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 12, Issue 9, Pages: 28-30(2006)
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- Published：2006
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OUYANG Jian-jun 1, WU Can-rong1, CHEN Bei-yang1, et al. The Influence of YUEHUA Capsule(YHC) on T Ly Mphocyte Subgroups and Cytokines in Rats with Multi-drug Resistant Tuberculosis(MDR-TB)[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(9): 28-30.
DOI：

OUYANG Jian-jun 1, WU Can-rong1, CHEN Bei-yang1, et al. The Influence of YUEHUA Capsule(YHC) on T Ly Mphocyte Subgroups and Cytokines in Rats with Multi-drug Resistant Tuberculosis(MDR-TB)[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(9): 28-30. DOI：

摘要

目的:观察月华胶囊对耐多药结核鼠T淋巴细胞亚群、TH1/TH2细胞因子的影响及其机理。方法:将耐多药结核鼠随机分成模型组、月华胶囊组、抗结核药(OEZD)组、月华胶囊+抗结核药组

另设正常组。测各组中的CD4、CD8、CD4/CD8、IFN-γ、IL-2、IL-10、TNF-α。结果:①与模型组比较

月华胶囊组、抗结核药组、月华胶囊+抗结核药组均明显减少CD4、CD4/CD8、INF-γ、IL-2降低(P<0.01)

明显改善IL-10、INF-α升高(P<0.05);②与抗结核药组比较

月华胶囊+抗结核药组各指标差异均有显著性(P<0.05)。结论:月华胶囊对耐多药结核鼠有治疗作用

其机理是通过调控T淋巴细胞亚群CD4、CD4/CD8及其TH1型细胞因子IFN-γ、IL-2

TH2型细胞因子IL-10和TNF-α的水平而实现的。

Abstract

Objective:To observe the possible influence of YUEHUA capsule(YHC) on T Lymphocyte subgroup and TH1/TH2 cytokines in rats with Multi-drug resistant tuberculosis (MDR-TB) and its mechanism for this effect.Methods:The experimental rats

as the studying model

were Divided into the modeling group

YHC group

the drug of antituberculosis (OEZD) group and YHC & OEZD group in random process. And there was normal group. Then CD4+

CD8+

CD4+/CD8+

IFN-γ

IL-2

IL-10

and TNF-α were observed in the all group.Result:Compared with the modeling group

CD4+

CD4+/CD8+

IFN-γ and IL-2 were significantly controlled to go down(P<0.01)

and IL-10

INF-α were significantly controlled to go up (P<0.05) in YHC group

OEZD group and YHC & OEZD group. Compared with OEZD group

in YHC & OEZD group the findings were significantly different(P<0.05).Conclusion:YHC holds therapeutic effects on rats with MDR-TB. These effects may be associated with the controlled Level of CD4+

CD4+/CD8+ and TH1/TH2 cytokines

including IFN-γ

IL-2 and IL-10

and TNF-α.

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