The Nephrotoxicity of Long Dan Xie Gan Decoction and the Relevance with  Kom in the Decoction

ZHANG Na; Xie Ming

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The Nephrotoxicity of Long Dan Xie Gan Decoction and the Relevance with Kom in the Decoction

更新时间：2024-01-04

- The Nephrotoxicity of Long Dan Xie Gan Decoction and the Relevance with Kom in the Decoction
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 12, Issue 5, Pages: 58-61(2006)
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- Published：2006
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ZHANG Na, Xie Ming. The Nephrotoxicity of Long Dan Xie Gan Decoction and the Relevance with Kom in the Decoction[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(5): 58-61.
DOI：

ZHANG Na, Xie Ming. The Nephrotoxicity of Long Dan Xie Gan Decoction and the Relevance with Kom in the Decoction[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(5): 58-61. DOI：

摘要

目的:观察龙胆泻肝汤中关木通配伍与大鼠肾损伤的关系。方法:大鼠随机分为含关木通的龙胆泻肝汤(17.5g/kg)组、龙胆泻肝汤去关木通(11.5g/kg)组、单味关木通(6g/kg)组和正常对照组四组

前三组分别含关木通6g/kg给以相应方药水煎液灌胃

连续12周

对照组给予等量蒸馏水。于给药第4、8、12周分别测定各组大鼠肾功能及尿生化指标。结果:单味关木通(6g·kg-1)和含相同剂量关木通的龙胆泻肝汤连续给大鼠灌胃12周

均见有肾损伤表现

其中龙胆泻肝汤组损伤较单味关木通组轻;去关木通的龙胆泻肝汤连续给大鼠灌胃12周

未见肾功能明显损伤。结论:实验剂量的关木通可引起肾损伤

龙胆泻肝汤的肾毒性与方中关木通配伍相关

复方配伍对关木通的肾损伤可能有一定的减毒的作用。

Abstract

Objective:To observe the renal injury in rats induced by Long Dan Xie Gan decoction(LDXGD) and the compatibilition with Aristolochia manshriensis Kom in LDXGD.Method:Separate SD rats to four groups at random

and feed respectively LDXGD containing Aristolochia manshriensis Kom(17.5g·kg-1

containing Aristolochia manshriensis Kom 6g·kg-1

LDXGD removed Aristolochia manshriensis Kom(11.5g·kg-1

Aristolochia manshriensis Kom(6g·kg-1 and distilled water for 12 weeks.determine renal functional parameters on 4w

12w.Result:Both Aristolochia manshriensis Kom(6g·kg-1 and the LDXGD containing same dose Aristolochia manshriensis Kom induced significantly renal injury in rats during 12 weeks

and the former caused more seriously damage;the LDXGD removed Aristolochia manshriensis Kom didn't induce damage obviously in rats during 12 weeks.Conclusion:Aristolochia manshriensis Kom in experimental dosage can induce renal injury

and the real toxicity of LDXGD is correlated with the dose of Aristolochia manshriensis Kom in itself;the compatibilition in the complex prescription(LDXGD) relieve possibly the renal toxicity of Aristolochia manshriensis Kom.

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