Objective:To explore the effect of pomegranate leaf tannide (PLT) on lipid metabolite of high-lipid rats and its inhibition on HMG-CoA reductasein vitro.Methods:The high-lipid rat model and high-lipid wiih high-sugar mice model induced by intraperitoneal injection of alloxan were used.The contents of TC and TG of both models was measured.Rat liver microsome HMG-CoA reductase was prepare to measure the content changes of A340in 1minute.Results:PLT can remarkably decrease TC and TG of high-lipid rat at doses of 150 and 75 mg/kg

and its reducing effect on TC of high-lipid with high-sugar mice at doses of 300 and 75mg/kg is also obvious.The minimal inhibition concentration of HMG-CoA reductasein vitrois 1×10-6g/mL with inhibition percentage of 15.16%.Conclusion: PLT has a noticeable activity of modulating lipid metabolite of high-lipid rat and inhibiting HMG-CoA redutasein vitro.