Protective Effects of Divitamins Notonginseng and Cinnarizine Capsules on Global Cerebral Ischemia Reperfusion Injury of Rats

GAO Jun-wei1; DENG Xiu-ling1; MAO Hai-yan2; YUAN Bing-xiang1; WANG Yan1

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Protective Effects of Divitamins Notonginseng and Cinnarizine Capsules on Global Cerebral Ischemia Reperfusion Injury of Rats

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- Protective Effects of Divitamins Notonginseng and Cinnarizine Capsules on Global Cerebral Ischemia Reperfusion Injury of Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 11, Issue 5, Pages: 36-39(2005)
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- Published：2005
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GAO Jun-wei1, DENG Xiu-ling1, MAO Hai-yan2, et al. Protective Effects of Divitamins Notonginseng and Cinnarizine Capsules on Global Cerebral Ischemia Reperfusion Injury of Rats[J]. Chinese journal of experimental traditional medical formulae, 2005, 11(5): 36-39.
DOI：

GAO Jun-wei1, DENG Xiu-ling1, MAO Hai-yan2, et al. Protective Effects of Divitamins Notonginseng and Cinnarizine Capsules on Global Cerebral Ischemia Reperfusion Injury of Rats[J]. Chinese journal of experimental traditional medical formulae, 2005, 11(5): 36-39. DOI：

摘要

目的:探讨二维三七桂利嗪胶囊(DNCC)对全脑缺血再灌注损伤的疗效；方法:阻断大鼠四动脉血流10min

再灌注72h制成全脑缺血再灌注模型；观察DNCC对全脑缺血再灌注大鼠脑电图、学习记忆、脑指数、脑含水量及海马区神经元变化的影响。结果:DNCC能降低全脑缺血后脑电图的下降幅度

缩短再灌注后脑电图的恢复时间；提高全脑缺血再灌注损伤大鼠的学习记忆能力；可降低脑指数及脑含水量；再灌流72h后海马CA1区存活的细胞数高于模型组。结论:DNCC对全脑缺血再灌注具有明显的保护作用。

Abstract

Objective:To evaluate the efficacy of Divitamins Notonginseng and Cinnarizine Capsules(DNCC) on the global cerebral ischemia reperfuion injury.Methods:Ligating bilateral common carotid arteries and bilateral centrum arteries for ten minutes

and then reperfusing 72 hours induced the global cerebral ischemia reperfusion model.Observing the influence of DNCC on theelectroencephalogram(EEG)

learning and memorizing abilities

brain index

water containing

and the number of the neuron alive.Results:DNCC can obviously reduce the decreasing scope of EEG

short recovering time of EEG after reperfusion

reduce learning and memorizing disturbance

brain index and water containing

and improve the living cells at hippocampi after reperfusion for 72 hours.Conclusion:DNCC can strongly protect the brains impaired by global cerebral ischemia reperfusion.

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Related Author

GAO Jun-wei1

DENG Xiu-ling1

MAO Hai-yan2

YUAN Bing-xiang1

WANG Yan1

QIN Yingying

LI Peng

CHEN Sha

Related Institution

西安交通大学医学院陕西西安710061

2 Department of Neurosurgery,The First Hospital of Xi’an Jiao-tong University

1 Department of Pharmacology,Medical College of Xi’an Jiaotong University

School of Basic Science，Shanxi Key Laboratory for Modernization of Traditional Chinese Veterinary Medicine，Shanxi Agricultural University

School of Chinese Materia Medica，Chongqing University of Chinese Medicine

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