The Anti-respiratory Syncyntial Virus Effect of Qing Re He Ji

ZHAO Li-mei1; ZHANG Yan2; HAN Guo-zhu2

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The Anti-respiratory Syncyntial Virus Effect of Qing Re He Ji

更新时间：2024-01-04

- The Anti-respiratory Syncyntial Virus Effect of Qing Re He Ji
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 12, Issue 1, Pages: 53-55(2006)
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- Published：2006
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ZHAO Li-mei1, ZHANG Yan2, HAN Guo-zhu2. The Anti-respiratory Syncyntial Virus Effect of Qing Re He Ji[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(1): 53-55.
DOI：

ZHAO Li-mei1, ZHANG Yan2, HAN Guo-zhu2. The Anti-respiratory Syncyntial Virus Effect of Qing Re He Ji[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(1): 53-55. DOI：

摘要

目的:了解清热合剂对呼吸道合胞病毒(RSV)的抑制作用。方法:采用细胞培养技术

以双黄连为阳性对照药

观察清热合剂在非洲绿猴肾细胞(VERO)和咽喉癌上皮细胞(HEP-2)细胞中对RSV的抑制作用。结果:在VERO细胞中

清热合剂半数中毒浓度(TD50)为31.62mg/mL

抗合胞病毒的半数有效浓度(IC50)为0.50mg/mL

治疗指数(TI)为63.24;在HEP-2细胞中

TD50为32.10mg/mL

抗合胞病毒的IC50为0.54mg/mL

TI为59.44。且对RSV抑制作用存在明显的量效反应关系(P<0.01)。结论:清热合剂在VERO和HEP-2细胞中对RSV有明显抑制作用。

Abstract

Objective:To observe the anti-respiratory syncyntial virus(RSV) effect of Qing Re He Ji(QRHJ).Methods:The anti-RSV effect of QRHJ was observed by means of the technique of VERO and HEP-2 cell culture using Shuang Huang Lian as a positive control.Results:In VERO and HEP-2 cell culture

QRHJ was a potential inhibitor of RSV in concentration-dependent manner(P<0.01).The TD50 was 31.62mg/mL

the IC50 was 0.50mg/mL and TI was 63.24 in VERO cell culture.The TD50 was 32.10mg/mL

the IC50 was 0.54mg/mL and TI was 59.44 in HEP-2 cell culture.Conclusion:QRHJ has a significant anti-RSV effect in VERO and HEP-2 cell culture

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