Effects of Chuanxiong-Chishao Dispensing Ratio on the Pharmacokinetics of Ferulic Acid in Canine

ZHANG Zhuang1; LIU Nan1; CHEN Ke-ji2; YAN Yan-fang1

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Effects of Chuanxiong-Chishao Dispensing Ratio on the Pharmacokinetics of Ferulic Acid in Canine

更新时间：2024-01-04

- Effects of Chuanxiong-Chishao Dispensing Ratio on the Pharmacokinetics of Ferulic Acid in Canine
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 11, Issue 3, Pages: 28-31(2005)
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- Published：2005
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ZHANG Zhuang1, LIU Nan1, CHEN Ke-ji2, et al. Effects of Chuanxiong-Chishao Dispensing Ratio on the Pharmacokinetics of Ferulic Acid in Canine[J]. Chinese journal of experimental traditional medical formulae, 2005, 11(3): 28-31.
DOI：

ZHANG Zhuang1, LIU Nan1, CHEN Ke-ji2, et al. Effects of Chuanxiong-Chishao Dispensing Ratio on the Pharmacokinetics of Ferulic Acid in Canine[J]. Chinese journal of experimental traditional medical formulae, 2005, 11(3): 28-31. DOI：

摘要

目的:探索中药配伍比例对中药复方中的药效成分药代动力学特征的影响。方法:采用反相高效液相色谱法紫外检测阿魏酸血清药物浓度

3P87药代动力学软件拟合药代动力学模型

统计学处理采用t检验法。结果:川芎:赤芍1∶2和2∶1芎芍制剂给予麻醉犬灌胃5g·kg-1后阿魏酸的药代动力学过程均符合一室开放模型

川芎∶赤芍1∶2和2∶1组的药动学参数分别为Ka=0.111±0.035(min-1)和0.075±0.020(min-1)

Ke=0.013±0.004(min-1)和0.016±0.002(min-1)

t1/2Ka=6.701±1.926(min)和9.735±2.377(min)

t1/2Ke=6.1306±2.3531(min)和4.4254±5.518(min)

tpeak=24.915±5.307(min)和29339±4.101(min)

cmax=557.797±172.903(μg·L-1)和1509.518±275.813(μg·L-1)；两组间药动学参数Ka与t1/2Ka的差异具有显著统计学意义(P<0.05)。结论:川芎赤芍配伍比例对阿魏酸的药动学特征具有显著影响

揭示中药配伍比例的差异有时会导致其中某一种成分的药代动力学特征的变化。

Abstract

Objective: To explore the effects of dispensing ratio of Chinese herbs on the pharmacokinetics characteristics of effective component.Methods: Ferulic Acid(FA)in serum was determined by RP-HPLC with UV-detector.The concentration-time data were fitted using 3P87 Pharmacokinetic Program

and the pharmacokinetic parameters were compared byt-test.Results: By adminstrating Xiongshao preparation of 5 g·kg-1intragastically

the concentration-time curves of FA in canine groups of Chuanxiong: Chishao=1∶2 and Chuanxiong:Chishao=2∶1 both fitted to open one-compartment model.Parameters of Chuanxiong:Chishao=1∶2 and Chuanxiong:Chishao=2∶1 group were:Ka=0.111±0.035(min-1) and 0.075±0.020(min-1)

Ke=0.013±0.004(min-1) and 0.016±0.002(min-1)

t1/2Ka=6.701±1.926(min) and 9.735±2.377(min)

t1/2Ke= 61.306±23.531(min) and 44.254±5.518(min)

tpeak=24.915±5.307(min) and 29.339±4.101(min)

cmax=557.797±172.903(μg·L-1) and 1509.518±275.813(μg·L-1)accordingly.The differences of pharmacokinetic parametersKaandt1/2Kabetween the two groups were statistically significant(P<0.05 ).Conclusion:The difference in dispensing ratio of herbs in Chinese formulae may result in changes of the pharmacokinetic characteristics of the components.

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Related Author

ZHANG Zhuang

QIN La-mei

CHEN Ke-ji

刘东锋1

张莉2

陈婷2

LI Yin-chao

ZHOU Tian

Related Institution

School of Life Sciences，Beijing University of Chinese Medicine

School of Pharmacy，Shanghai University of Traditional Chinese Medicine

School of Graduate Studies，Tianjin University of Traditional Chinese Medicine（TCM）

The Second Affiliated Hospital of Tianjin University of TCM

First Teaching Hospital of Tianjin University of TCM

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