Effects of Active Fractions of Danshen or Sanqi on Platelet Adhesion,Aggregation and TXA,PGI in Normal Rats

YANG Jia1; Zhang Yi1; QIN Cai-ling1; SUI You-fu1; TAN Hong-gen1; ZHANG Shu-yun1; -WU Gui-lan1; Liu Ting1; ZHANG Bo-li2

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Effects of Active Fractions of Danshen or Sanqi on Platelet Adhesion,Aggregation and TXA,PGI in Normal Rats

更新时间：2024-01-04

- Effects of Active Fractions of Danshen or Sanqi on Platelet Adhesion,Aggregation and TXA,PGI in Normal Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 10, Issue 5, Pages: 21-24(2004)
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- Published：2004
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YANG Jia1, Zhang Yi1, QIN Cai-ling1, et al. Effects of Active Fractions of Danshen or Sanqi on Platelet Adhesion,Aggregation and TXA,PGI in Normal Rats[J]. Chinese journal of experimental traditional medical formulae, 2004, 10(5): 21-24.
DOI：

YANG Jia1, Zhang Yi1, QIN Cai-ling1, et al. Effects of Active Fractions of Danshen or Sanqi on Platelet Adhesion,Aggregation and TXA,PGI in Normal Rats[J]. Chinese journal of experimental traditional medical formulae, 2004, 10(5): 21-24. DOI：

摘要

观察了丹参、三七提取部位丹酚酸B、Rb、Re、Rg对正常大鼠血浆血小板粘聚性及TXA2、PGI2的影响。结果表明:灌胃给药

部位Re68mg/kg、Rg108mg/kg对ADP诱导正常大鼠血浆血小板聚集的作用显现出明显抑制作用;部位Rg108mg/kg、丹酚酸B48mg/kg可以明显抑制正常大鼠血浆血小板粘附性;部位Rb112mg/kg对血小板粘聚性均无明显影响;部位丹酚酸B48mg/kg、Rg108mg/kg明显降低血浆TXB2的水平

对6-Keto-PGF1α均无明显影响;部位Rg108mg/kg亦明显降低TXB26-Keto-PGF1α的比值。提示:推测丹参、三七有效部位丹酚酸B、Rg抑制正常大鼠血浆血小板粘聚性的作用机理可能与抑制TXA2的合成有关。

Abstract

We studied the effects of salvianolic acid B(Sa1.B)、Rb、Re and Rg fractions of Danshen or Sanqi on platelet aggregation and adhesion

TXA2 and PGI2 in normal rats. The results demonstrated that Re fraction (68mg/kg)and Rg fraction (108mg/kg)

given orally

could markedly counteract ADP induced platelet aggregation.Rg fraction (108mg/kg) and Sal.B fraction(48mg/kg) could markedly inhibit platelet adhesion.Rb fraction(112mg/kg) have no effects on platelet aggregation and on adhesion.Rg fraction(108mg/kg) and Sal.B fraction (48mg/kg) could markedly decrease the level of TXA2

but had little effect on 6-Keto-PGF1α. Moreover

Rg fraction 108mg/kg could decrease the ration of TXB2/6-Keto-PGF1α

too. The results suggested that the inhibition effects on platelet aggregation and adhesion of Rg fraction(108mg/kg) and Sal.B fraction(48mg/kg) of Danshen or Sanqi might be closely related to its inhibition effect on the release of TXA2 in normal rats.

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