Influence of Two Kinds of Active Components from Panax Notoginseng on NO and iNOS in Inflammatory Metrorrhagia Model of

YOU Zhao-ling1; MA Hong-xia2; WANG Ruo-guang1; TAN Zhen-ru1; LIN Jie1; YU Jian1

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Influence of Two Kinds of Active Components from Panax Notoginseng on NO and iNOS in Inflammatory Metrorrhagia Model of

更新时间：2024-01-04

- Influence of Two Kinds of Active Components from Panax Notoginseng on NO and iNOS in Inflammatory Metrorrhagia Model of
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 10, Issue 5, Pages: 18-20(2004)
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- Published：2004
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YOU Zhao-ling1, MA Hong-xia2, WANG Ruo-guang1, et al. Influence of Two Kinds of Active Components from Panax Notoginseng on NO and iNOS in Inflammatory Metrorrhagia Model of [J]. Chinese journal of experimental traditional medical formulae, 2004, 10(5): 18-20.
DOI：

YOU Zhao-ling1, MA Hong-xia2, WANG Ruo-guang1, et al. Influence of Two Kinds of Active Components from Panax Notoginseng on NO and iNOS in Inflammatory Metrorrhagia Model of [J]. Chinese journal of experimental traditional medical formulae, 2004, 10(5): 18-20. DOI：

摘要

目的:探讨一氧化氮(NO)及诱导型一氧化氮合酶(iNOS)在炎性子宫出血中的作用及三七复合有效成分的影响。方法:选择月经正常雌性育龄恒河猴11只

随机分为中药组(三七复合有效成分)4只、模型组4只及正常对照组3只。应用化学比色法检测三组子宫内膜中一氧化氮及一氧化氮合酶的活性

用免疫组化法检测三组子宫内膜中一氧化氮合酶(iNOS)蛋白的表达水平。结果:中药组与模型组比较

子宫内膜NO、iNOS的活性及iNOS蛋白表达水平明显降低

差异有显著性

P0.01;结论:NO可能参与了炎性子宫出血的发病机制

三七减少炎性子宫出血的机制可能与调节NO、iNOS的活性及iNOS蛋白表达水平有关。

Abstract

Objective:To explore the influence of two kinds of active components from Panax notoginseng on NO and iNOS on inflammatory Metrorrhagia model of Macaca multatta. Methods:Eleven normal menorrhea adult Rhesus monkeys were choosed as research object

and were divided into model group (four)

TCM group(four) and Control group(three) at random.Colorimetric method were performed to estimate the activity of NO and iNOS in of model group

TCM group and normal control group

the immunohistochemical S-p were performed to estimate the express level of iNOS in the endometrium of the three groups.Result:Compared to the model group

the activity of No and iNOS and the express level of iNOS in the endometrium of TCM gorup was obviously weaker

which are similar to that of the normal group.Conclusion:NO may be involred in the pathogenesis of inflammatory Metrorrhagia.Two kinds of active components from Panax notoginseng reduce inflammatory Metrorrhagia by regulating the activities of NO and iNOS and the express level of iNOS in the endometrium.

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Related Institution

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Affiliated Ruikang Hospital to Guangxi Traditional Chinese Medicine University

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