Comparison for Pharmacokinetics of Osthole Contained in Antifebrile Complex YL2000 Between Normal and Febrile Rats

XING Dong-ming1; ZHAO Yu-nan1; SHI Yue1; SUN Li-hong2; WANG Wei1; DING Yi1; DU Li-jun1

您当前的位置：

首页 >

文章列表页 >

Comparison for Pharmacokinetics of Osthole Contained in Antifebrile Complex YL2000 Between Normal and Febrile Rats

更新时间：2024-01-04

- Comparison for Pharmacokinetics of Osthole Contained in Antifebrile Complex YL2000 Between Normal and Febrile Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 10, Issue 2, Pages: 30-33(2004)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2004
- 稿件说明：
移动端阅览
XING Dong-ming1, ZHAO Yu-nan1, SHI Yue1, et al. Comparison for Pharmacokinetics of Osthole Contained in Antifebrile Complex YL2000 Between Normal and Febrile Rats[J]. Chinese journal of experimental traditional medical formulae, 2004, 10(2): 30-33.
DOI：

XING Dong-ming1, ZHAO Yu-nan1, SHI Yue1, et al. Comparison for Pharmacokinetics of Osthole Contained in Antifebrile Complex YL2000 Between Normal and Febrile Rats[J]. Chinese journal of experimental traditional medical formulae, 2004, 10(2): 30-33. DOI：

摘要

目的:探讨中药有效部位新药YL2000中蛇床子素在正常和发热大鼠体内的代谢动力学。方法:采用高效液相色谱技术分别测定正常大鼠和干酵母致发热大鼠血浆中蛇床子素的含量

使用3P87软件处理蛇床子素的时量数据

计算各药代动力学参数。结果:在正常和发热大鼠体内

蛇床子素的达峰时间分别为1.62h和4.02h

峰值血药浓度分别达0.03ug/ml和0.04ug/ml

t1/2(ke)分别长达2.98h和2.00h

t1/2(ka)分别为0.43h和1.09h

CL/F值分别为4221(mg/kg)h/(ug/ml)和2715(mg/kg)h(ug/ml)

AUC(0-T)值分别为0.189(ugml)*h和0.29(ug/ml)*h。结论:发热对蛇床子素的药动学有一定的影响

可以延缓它的吸收

增加它的吸收率

最终导致模型组的AUC(0-T)增大。

Abstract

Objective:To explore pharmacokinetics for osthole of YL2000 in normal and febrile rats. Methods:The levels of osthole in plasma were measured through HPLC and the secondary parameters were obtained by fitting the osthole concentration-time data using 3P87 software. Results:In normal and febrile rats

the plasma concentration of osthole was peaked at 1.62h vs.4.02h with a level of 0.03ug/ml vs. 0.04ug/ml

and the t1/2(ke)

t1/2(ka)

CL/F and AUC(0-T) of osthole was 2.98h vs. 2.00h

0.43h vs. 1.09h

4221(mg/kg)/h/(ug/ml) vs.2715(mg/kg)/h/(ug/ml) and 0.189(ug/ml)*h vs. 0.29(ug/ml)*h

respectively. Conclusion:Fever induced effects on pharmacokinetics of osthole

including delay of absorption and increas in AUC(0-T).

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Pharmacokinetics of Curcumin Microcystin in Rats

Formulation Optimization and Quality Evaluation of Osthole Solid Dispersion Dispersible Tablets

Pharmacokinetics of Curcumin Microcystin in Rats

Comparison of Pharmacokinetics and Tissue Distribution of Free Anthraquinones and Gallic Acid in Mice with Ulcerative Colitis Before and After Processing of Rhei Radix et Rhizoma Carbonisata

Pharmacokinetic Differences of Seven Components in Different Phases of Banxia Xiexintang in Rats

Related Author

ZENG Xiao-hui

CHEN Yu-xing

ZHAO Zi-ming

HUANG Xue-jun

DU Tie-liang

YU Di-jia

LIU Yang

ZHU Ying

Related Institution

Guangdong Provincial Institute of Traditional Chinese Medicine

School of Life Sciences，Beijing University of Chinese Medicine

School of Pharmacy，Shanghai University of Traditional Chinese Medicine

School of Graduate Studies，Tianjin University of Traditional Chinese Medicine（TCM）

The Second Affiliated Hospital of Tianjin University of TCM

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰