Effects of Fufangdanshenfang on Platelet Adhesion,Aggregation and TXB、6-Keto-PGF in Blood Stasis Syndromes Model Rats

Liu Ting1; QIN Cai-ling1; ZHANG Ying1; YANG Jia1; SUN You-fu1; ZHANG Shu-yun1; ZHANG Bo-li2

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Effects of Fufangdanshenfang on Platelet Adhesion,Aggregation and TXB、6-Keto-PGF in Blood Stasis Syndromes Model Rats

更新时间：2024-01-04

- Effects of Fufangdanshenfang on Platelet Adhesion,Aggregation and TXB、6-Keto-PGF in Blood Stasis Syndromes Model Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 10, Issue 4, Pages: 35-38(2004)
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Liu Ting1, QIN Cai-ling1, ZHANG Ying1, et al. Effects of Fufangdanshenfang on Platelet Adhesion,Aggregation and TXB、6-Keto-PGF in Blood Stasis Syndromes Model Rats[J]. Chinese journal of experimental traditional medical formulae, 2004, 10(4): 35-38.
DOI：

Liu Ting1, QIN Cai-ling1, ZHANG Ying1, et al. Effects of Fufangdanshenfang on Platelet Adhesion,Aggregation and TXB、6-Keto-PGF in Blood Stasis Syndromes Model Rats[J]. Chinese journal of experimental traditional medical formulae, 2004, 10(4): 35-38. DOI：

摘要

目的:研究复方丹参方对肾上腺素血瘀模型大鼠血小板粘聚性及TXB2、6-Keto-PGF1α含量的影响。方法:采用皮下注射肾上腺素加冰水冷浴法造大鼠血瘀模型

观察复方丹参方对血小板粘聚性及TXB2、6-Keto-PGF1α含量的影响。结果:大鼠肾上腺素血瘀模型组与正常对照组比较

血浆血小板聚集性、粘附性均显著升高;复方丹参方对肾上腺素血瘀模型大鼠血小板粘聚性升高有明显抑制作用

对血浆中TXB2及血浆中6-Keto-PGF1α、腹主动脉组织6-Keto-PGF1α均有明显升高的作用

对TXB26-Keto-PGF1α无明显影响。结论:此血瘀模型复制成功

推测其升高血小板粘聚性的机理与TXB2PGI2系统无明显关系。复方丹参方对肾上腺素血瘀模型大鼠血小板粘聚性升高有明显抑制作用。

Abstract

Ojbect:To study the effects of Fufangdanshenfang on Platelet Adhesion

Aggregation and TXB2、6-Keto-PGF1α in Blood Stasis Syndromes Model Rats.Methods:The rat blood stasis syndromes model was caused by subcutaneous injection of Adr and ice-bathing.We studied the effects of Fufangdanshenfang on platelet aggregation

adhesion

TXB2 and 6-Keto-PGF1α in blood stasis syndromes model rats.Results:The results indicated that compared with normal rats

the platelet aggregation and platelet adhesion were markedly increased.Fufangdancanfang was antagonized the increase of platelet adhesion and ADP-induced platelet aggregation in model rats.Fufangdancanfang markedly increased the level of TXB2、6-Keto-PGF1α in plasma and the content of abdominal aorta tissue 6-Keto-PGF1α in model rats

but had little effect on the proportion of TXB2/6-Keto-PGF1α.Conclusion:The results suggested that rat blood stasis syndromes model of Adr was caused successfully

and we inferred that the effects on the platelet aggregation and platelet adhesion might not be connected with the system TXB2-PGI2.Fufangdancanfang was antagonized the increase of platelet adhesion and ADP-induced platelet aggregation in model rats.

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