The Express and Principle Study of Liver Toxicity of
|更新时间:2024-01-04
|
The Express and Principle Study of Liver Toxicity of
Chinese Journal of Experimental Traditional Medical FormulaeVol. 11, Issue 1, Pages: 40-42(2005)
作者机构:
作者简介:
基金信息:
DOI:
CLC:
Published:2005
稿件说明:
移动端阅览
LI Yu-jie1, Liu Shumin2, LUO Ming-mei2, et al. The Express and Principle Study of Liver Toxicity of [J]. Chinese journal of experimental traditional medical formulae, 2005, 11(1): 40-42.
DOI:
LI Yu-jie1, Liu Shumin2, LUO Ming-mei2, et al. The Express and Principle Study of Liver Toxicity of [J]. Chinese journal of experimental traditional medical formulae, 2005, 11(1): 40-42.DOI:
The Express and Principle Study of Liver Toxicity of
Objective:To discuss the indexes and principle ofDioscorea bulbifera Lliver toxicity.Method:Dioscorea bulbifera L
2g/kg d
10g/kg d
50g/kg d were given to mice which lasted 21 days
and observe the change of biochemical indexes
the activity of medicine metabolizability enzyme and anti-oxidation enzyme and pathology results.Result:Dioscorea bulbifera Lcan increase the GPT
GOT
ATP and TBIL levels and decrease the GST
GSH and SOD activity in mice
both of which is relevant to time and dosage.The pathology changes included looseness
tumidness
karyon dissolution
amalgamation
putrescence
confluent hepatic duct district inflammatory cells corrasion and small bile duct edema and hyperplasia.Conclusion:The indexes ofDioscorea bulbifera Ltoxicity are GPT
GOT
ATP
TBIL and tissue changes.The principle of toxicity is relevant to its inhibition of the activity of medicine metabolizability enzyme and anti-oxidation enzyme in liver mitochondria.