Inhibitory Effect and Antiangiogenesis of Gubenxiaoliu Capsule on Lewis Lung Carcinoma of Mouse

YANG Guo-wang1; WANG Xiao-min1; WANG Zheng2; PENG-Rui-yun3; GAO Ya-bing3; WANG Xiao-min3

您当前的位置：

首页 >

文章列表页 >

Inhibitory Effect and Antiangiogenesis of Gubenxiaoliu Capsule on Lewis Lung Carcinoma of Mouse

更新时间：2024-01-04

- Inhibitory Effect and Antiangiogenesis of Gubenxiaoliu Capsule on Lewis Lung Carcinoma of Mouse
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 10, Issue 5, Pages: 50-52(2004)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2004
- 稿件说明：
移动端阅览
YANG Guo-wang1, WANG Xiao-min1, WANG Zheng2, et al. Inhibitory Effect and Antiangiogenesis of Gubenxiaoliu Capsule on Lewis Lung Carcinoma of Mouse[J]. Chinese journal of experimental traditional medical formulae, 2004, 10(5): 50-52.
DOI：

YANG Guo-wang1, WANG Xiao-min1, WANG Zheng2, et al. Inhibitory Effect and Antiangiogenesis of Gubenxiaoliu Capsule on Lewis Lung Carcinoma of Mouse[J]. Chinese journal of experimental traditional medical formulae, 2004, 10(5): 50-52. DOI：

摘要

目的:探讨中药固本消瘤胶囊对小鼠Lewis肺癌抑瘤作用及机制。方法:体内动物实验观察小鼠肿瘤生长;免疫组化染色S-P法、病理彩色图像定量分析法检测小鼠肿瘤组织中微血管密度(MVD)、血管内皮生长因子(VEGF)表达。结果:中药组、化疗组、中药加化疗组对小鼠Lewis肺癌抑制率分别为为40.5%、52.69%、61.09%

与对照组比较有显著差异(P<0.01)。中药组、中药加化疗组MVD、VEGF表达水平以及化疗组MVD水平明显下降。结论:固本消瘤胶囊对小鼠Lewis肺癌有明显抑制作用

能够抗肿瘤新生血管生成。

Abstract

Objective:To explore the inhibitory effect of tumor growth and antiangiogenesis of Gubenxiaoliu capsule(GC) on Lewis lung carcinoma of mouse.Methods:In vivo animal experiment was used to investigate the growth of mouse tumor.Immunohistochemically(S-P) and quantitative pathologic image analysis were used to investigate the microvesel dencity(MVD) and expression of vascular endothelial growth factor(VEGF) in tumor tissue.Results:The inhibitory rates on mouse tumor of GC group

Chemotherapy group and GC+Chemotherapy group are 40.58%

52.69%

61.09% respectively

The inhibitory rates are significantly higher than the control

MVD and expression of VEGF of GC group and GC+Chemotherapy group and MVD of Chemotherapy group decreased significantly.Conelusion:GC could inhibit the growth and angiogenesis of Lewis lung carcinoma of mouse.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

The Expression of Bax Proteinum of Fructus Corni Polysaccharides in Human Cervical Cancer Cells

Effects of Qian Lie Shuang Granule on the Expression of IL-10, TNF- in the Rat Model for Chronic Abacterial Prostatitis

Resistance Effect and Mechanism of Radix of Combined with Jujubae Fructus on Cirrhosis in Rats

Effect of Danzhi Jiangtang Capsule on Vasculopathy of Type 2 Diabetes Mellitus Rat Models Based on p38MAPK Pathway

Related Author

LIU Bin

ZHOU Yan-fen

YANG Huan-huan

WANG Zhe

JIN Yi

WANG En-jun

ZHANG Lan-lan

SUN Yu-hua

Related Institution

No data

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰