Effects of Qilan Tangzhi Ning on TXB and 6-Keto-PGF in Rats with Diabetes Mellitus and Hyperlipemia
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Effects of Qilan Tangzhi Ning on TXB and 6-Keto-PGF in Rats with Diabetes Mellitus and Hyperlipemia
Chinese Journal of Experimental Traditional Medical FormulaeVol. 11, Issue 2, Pages: 43-45(2005)
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Published:2005
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ZHANG De-qin, GAO Xue-min, ZHANG Jian-jun, et al. Effects of Qilan Tangzhi Ning on TXB and 6-Keto-PGF in Rats with Diabetes Mellitus and Hyperlipemia[J]. Chinese journal of experimental traditional medical formulae, 2005, 11(2): 43-45.
DOI:
ZHANG De-qin, GAO Xue-min, ZHANG Jian-jun, et al. Effects of Qilan Tangzhi Ning on TXB and 6-Keto-PGF in Rats with Diabetes Mellitus and Hyperlipemia[J]. Chinese journal of experimental traditional medical formulae, 2005, 11(2): 43-45.DOI:
Effects of Qilan Tangzhi Ning on TXB and 6-Keto-PGF in Rats with Diabetes Mellitus and Hyperlipemia
Objective:To study the mechanism of Qilan Tangzhi Ning capsule improving the blood stagnation in rats with diabetes mellitus and hyperlipemia.Methods:Rats were fed with high sugar and fat food for 2 months
then 2% streptozocin(STZ
30 mg·kg-1) was injected intraperitoneally to induce hyperglycemia and hyperlipemia.After the model rats were administrated drugs for 30 days
the blood glucose
the serum lipids
the plasma TXB2 and 6-Keto-PGF1α were detected.Results:Qilan Tangzhi Ning capsule could decrease the FBG and the serum TC
TG
LDL-C
increase HDL-C
decrease the TXB2
increase the 6-Keto-PGF1αand decrease TXB2/6-keto-PGF1α.Conclusion:Qilan Tangzhi Ning Capsule can adjust the balance of TXB2and 6-Keto-PGF1α to improve the blood stagnation
and prevent pathological changes of blood vessels in diabetes mellitus accordingly.