Study on the Formula of Dingzhi Xiaowan (NO.1)

FAN Gan-bin; MA Shi-ping; XI Wen-yu

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Study on the Formula of Dingzhi Xiaowan (NO.1)

更新时间：2024-01-04

- Study on the Formula of Dingzhi Xiaowan (NO.1)
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 11, Issue 3, Pages: 8-11(2005)
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- Published：2005
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FAN Gan-bin, MA Shi-ping, XI Wen-yu. Study on the Formula of Dingzhi Xiaowan (NO.1)[J]. Chinese journal of experimental traditional medical formulae, 2005, 11(3): 8-11.
DOI：

FAN Gan-bin, MA Shi-ping, XI Wen-yu. Study on the Formula of Dingzhi Xiaowan (NO.1)[J]. Chinese journal of experimental traditional medical formulae, 2005, 11(3): 8-11. DOI：

摘要

目的:研究定志小丸的组方规律

探索其组成药物(人参、远志、石菖蒲、茯苓)之间的最佳用量配伍比例。方法:采用正交试验设计对方中组成药物进行药味及药量的加减拆方

检测各方对小鼠学习记忆能力和脑内乙酰胆碱酯酶(AchE)活力的影响。结果:试验表明

全方的益智作用大于其它方。人参益智作用最强

其余依次为远志、石菖蒲、茯苓。方中各药的最佳用量配伍比例为3∶2∶0.6∶3。结论:定志小丸全方的益智作用最强

方中四味药物的最佳用量配伍比例与原方基本一致

表明定志小丸的用量配比较为合理。

Abstract

Objective:To study the formula of Dingzhi Xiaowan

and discuss the best proportion of four chinese medicines which compose it.Methods:Detect the ability of learning

memory and the energy of acetylcholine esterase (AchE) of the mice which were treated with different solutions prepared according to the orthogonal layout.Results & Conclusion:The effects of the formula composed of all four chinese medicines are better than others.Among the four Chinese medicines

Radix Ginseng presented the most significant effects on improving the ability of learning and memory in model mice

whereas Radix Polygalae

Rhizoma Acori Tatarinowii and Poria exhibited the attenuated properties in turn.This study showed that the best proportion of four Chinese medicines should be 3∶2∶0.6∶3 and indicated that the traditional proportion was reasonable.

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Related Institution

State Key Laboratory of Traditional Chinese Medicine Syndrome（TCM），The Second Affiliated Hospital of Guangzhou University of Chinese Medicine/Guangdong Provincial Hospital of Chinese Medicine/ Guangdong Branch of Chinese Academy of Chinese Medical Sciences

Guangdong Provincial Key Laboratory of Research on Emergency in TCM

Guangzhou University of Chinese Medicine

Shenzhen Bao'an TCM Hospital/Bao'an TCM Hospital Affiliated to Guangzhou University of Chinese Medicine

The First Affiliated Hospital of Guangzhou Medical University

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