Inhibitory Effect of  Extract on DEN-induced Precancerous Hepatic in Rats

ZHANG Xue-wu; ZHANG Xue-bin2

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Inhibitory Effect of Extract on DEN-induced Precancerous Hepatic in Rats

更新时间：2024-01-04

- Inhibitory Effect of Extract on DEN-induced Precancerous Hepatic in Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 10, Issue 4, Pages: 33-35(2004)
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- Published：2004
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ZHANG Xue-wu, ZHANG Xue-bin2. Inhibitory Effect of Extract on DEN-induced Precancerous Hepatic in Rats[J]. Chinese journal of experimental traditional medical formulae, 2004, 10(4): 33-35.
DOI：

ZHANG Xue-wu, ZHANG Xue-bin2. Inhibitory Effect of Extract on DEN-induced Precancerous Hepatic in Rats[J]. Chinese journal of experimental traditional medical formulae, 2004, 10(4): 33-35. DOI：

摘要

目的:研究珍珠梅提取物对二乙基亚硝胺(diethylnitrosamine

DEN)致大鼠肝脏癌前病变的抑制作用。方法:给动物ig给药

用DEN制备大鼠肝脏癌前病变模型;用免疫组织化学S-P法检测大鼠肝脏谷胱甘肽S-转移酶(GST-P)的表达水平

用比色分析法检测血清、肝匀浆、线粒体SOD、GSH-Px的活性及MDA含量的变化。结果:珍珠梅提取物能显著降低DEN致癌前病变大鼠肝脏GST-P的表达

升高血清、肝匀浆、肝线粒体SOD、GSH-Px的活性

降低MDA的含量。结论:珍珠梅提取物对DEN致大鼠肝脏癌变有抑制作用。

Abstract

Objective:To investigate the inhibitory effect of Sorbaria Sorbifolia extract on diethylnitrosamine (DEN) induced precancerous hepatic in rats.Methods:Sorbaria Sorbifolia was administrated ig. to rats with DEN-induced precarcinogenesis

Then using the immunohistochemical S-P method

the p53 and bcl-2 proteins were detected.The activities of superoxide dismutase(SOD)

glutathione peroxidase (GSH-Px)

and the concentrations of malondialdehyde(MDA) were investigated by colorimetric method.Results:Sorbaria Sorbifolia significantly decreased the expression of GST-P

and increased the SOD

GSH-Px and decreased MDA level in serum

liver cell homogenate and liver cell mitochondria.Conclusion:Sorbaria Sorbifolia extract has inhibitory effect on DEN-induced precancerous hepatic in rats.

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