Changes in Hypothalamus Proteins Levels of Yeast-Induced Febrile Rats Treated by Fr.A in Guizhi Tang

JIANG Nan; Huo Hai-ru; LI Lan-fang; Zhou Jun; LI Cang-hai; GUO Shu-ying; JIANG Ting-liang

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Changes in Hypothalamus Proteins Levels of Yeast-Induced Febrile Rats Treated by Fr.A in Guizhi Tang

更新时间：2024-01-04

- Changes in Hypothalamus Proteins Levels of Yeast-Induced Febrile Rats Treated by Fr.A in Guizhi Tang
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 10, Issue 3, Pages: 14-17(2004)
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- Published：2004
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JIANG Nan, Huo Hai-ru, LI Lan-fang, et al. Changes in Hypothalamus Proteins Levels of Yeast-Induced Febrile Rats Treated by Fr.A in Guizhi Tang[J]. Chinese journal of experimental traditional medical formulae, 2004, 10(3): 14-17.
DOI：

JIANG Nan, Huo Hai-ru, LI Lan-fang, et al. Changes in Hypothalamus Proteins Levels of Yeast-Induced Febrile Rats Treated by Fr.A in Guizhi Tang[J]. Chinese journal of experimental traditional medical formulae, 2004, 10(3): 14-17. DOI：

摘要

目的:观察桂枝汤有效部位A对酵母致热大鼠下丘脑组织蛋白质组的影响。方法:采用双向凝胶电泳技术和计算机辅助的图像分析方法

对蛋白质进行分离

以模型组作为参考胶进行匹配。结果:口服给予桂枝汤有效部位A后对发热大鼠有解热作用;双向电泳图像分析显示桂枝汤有效部位A与模型组匹配率为85%

多个蛋白质点表达量有不同程度的改变。结论:差异表达的蛋白质点可能与桂枝汤有效部位A解热作用有关。

Abstract

Objective:To observe the differential expressed protein spots in hypothalamus in yeast-induced febrile rats and the febrile rats treated with Fr.A

an active fraction extracted from Guizhi Tang.Methods:Using two-dimensional polyacrylamide gel electrophoresis(2-DE) and computer-assisted image analysis to separate and find the spots of interests.The febrile group gel was designated as reference gel.Results:The matching rate of the Fr.A treated group is 85% a few protein spots were changed more than 30 folds.Conclusion:The spots of interests may be identified as the proteins that associate with the febrile process

and/or the potential targets affected by Fr.A.They will be further analysised.

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