Objective:To explore the role of t-pA、PAI-1 in inflammatory Metrorrhagia and the influence of two kinds of active components on them.Methods:Eleven normal menorrhea adult Rhesus monkeys are choosed as research object

which are divided into four-model groups

four TCM group and three Control group at random.The hybridization in situ was performed to estimate the express of PAl-lmRNA in the endometrium of model group

TCM group and normal control group

while spectrophotometric assay was performed to estimate the t-pA activity in three groups.Result:The PAl-lmRNA expression in endometrum of TCM group Was higher than that of model group(P<0.05)

and was of no difference with normal group.The t-pA activity in endometrum of TCM group was significantly decreased than that of model group

and was of no difference with normal group.Conclusion:The increase of t-pA activity may have relation to inflammatory Metrorrhagia

and two kinds of active components from Panax notoginseng reduce inflammatory Metrorrhagia by regulating balance of t-pA and PAl-1.