Experimental Study of Shuang Ling Fuzheng Kangai Capsule(SLFKC) on Inhibiting Heps of Mouse

CHEN Huasheng1; XU Ai-hua1; WANG Zheng-bing1; JIA Lin-chang2; ZHAI Fan2

您当前的位置：

首页 >

文章列表页 >

Experimental Study of Shuang Ling Fuzheng Kangai Capsule(SLFKC) on Inhibiting Heps of Mouse

更新时间：2024-01-04

- Experimental Study of Shuang Ling Fuzheng Kangai Capsule(SLFKC) on Inhibiting Heps of Mouse
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 9, Issue 1, Pages: 45-46(2003)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2003
- 稿件说明：
移动端阅览
CHEN Huasheng1, XU Ai-hua1, WANG Zheng-bing1, et al. Experimental Study of Shuang Ling Fuzheng Kangai Capsule(SLFKC) on Inhibiting Heps of Mouse[J]. Chinese journal of experimental traditional medical formulae, 2003, 9(1): 45-46.
DOI：

CHEN Huasheng1, XU Ai-hua1, WANG Zheng-bing1, et al. Experimental Study of Shuang Ling Fuzheng Kangai Capsule(SLFKC) on Inhibiting Heps of Mouse[J]. Chinese journal of experimental traditional medical formulae, 2003, 9(1): 45-46. DOI：

摘要

目的:研究双苓扶正抗癌胶囊对小鼠肝癌的抑制作用及作用机制。方法:建立小鼠肝癌(Heps)实体瘤及腹水癌模型

观察抑瘤率和生命延长率

并用流式细胞术(FCM)检测小鼠肝癌实体瘤的细胞周期及癌细胞凋亡率。结果:双苓扶正抗癌胶囊在15g和30g/kg剂量下

对小鼠肝癌实体瘤有显著抑制作用

也能延长荷腹水型肝癌小鼠的生存期;还可引起小鼠肝癌瘤细胞S期及G2-M期细胞减少

G0-G1期细胞及凋亡细胞增加。结论:双苓扶正抗癌胶囊对小鼠移植性肝癌具有抑制作用

其作用机制可能与抑制细胞周期中S期DNA合成、干扰细胞的分裂增殖速度及诱导癌细胞凋亡有关。

Abstract

Objective:To study the inhibitory effect and mechanism in Heps of mouse with Shuang Ling Fuzheng Kangai Capsule(SLFKC). Method:Mouse model of the solid tumor and ascitic cancer were established.The inhibitory rate of solid tumor and the life prolongation rate of ascites cancer were observed.The cell cycle and apoptosis of the solid tumor cells were measured by Flow Cytometry(FCM). Results:SLFKC(15 and 30g.kg-1.d-1) had significant restraning effect on Heps of mouse and the life of ascites cancer bearing mice was also prolonged. SLFKC could decrease the number of cells in S and G2-M phase and increase the number of cells in G0-G1 phase and the number of apoptosis cells. Conclusion:SLFKC has inhibiting effect on Heps of mouse. The anticancer mechanism was probably related to the synthesis of DNA during S phase

the interference with the speed of cell proliferdtion

and inducement of the apoptosis of cancerous cells.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Inhibitory Effect of Sophora alopecuroides Total Alkaloids and Two Monomer Alkaloids on PC12 Cell Activity

Efficacy and Mechanism of Shenbai Jiedu Prescription Against Proliferation of HCT116 Cells

In Vitro Antitumor Bioactivity and GC-MS Analysis of Petroleum Ether Fraction of Boehmeria nivea Root

Research Review on Anti-cancer Action and Mechanism of

Inhibiting Effects of Flavonoids from on Human Lung Carcinoma Cell Line A-549

Related Author

GAO Li

LUO Fuxiang

ANAER Mahemuti

LUO Jingying

YAN Ming

Dong JIANG

Haibo CHENG

Weixing SHEN

Related Institution

Xinjiang Key Laboratory of Uighur Medical Prescription，Xinjiang Institute of Traditional Uighur Medicine

The First Clinical College of Nanjing University of Chinese Medicine

Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor

Jiangsu Province Hospital of Chinese Medicine，Affiliated Hospital of Nanjing University of Chinese Medicine

School of Pharmacy, Liaoning University of Traditional Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰