Protective Effect of the BSYZF-Contained Serum and its Subgroups on Aβ25-35 Induced NG108-15 Cells Injure

CHEN Yun-bo; LAI Shi-long; HU Jing-qing; Wang Qi; CHENG Shu-yi

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Protective Effect of the BSYZF-Contained Serum and its Subgroups on Aβ25-35 Induced NG108-15 Cells Injure

更新时间：2024-01-04

- Protective Effect of the BSYZF-Contained Serum and its Subgroups on Aβ25-35 Induced NG108-15 Cells Injure
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 8, Issue 5, Pages: 27-30(2002)
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- Published：2002
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CHEN Yun-bo, LAI Shi-long, HU Jing-qing, et al. Protective Effect of the BSYZF-Contained Serum and its Subgroups on Aβ25-35 Induced NG108-15 Cells Injure[J]. Chinese journal of experimental traditional medical formulae, 2002, 8(5): 27-30.
DOI：

CHEN Yun-bo, LAI Shi-long, HU Jing-qing, et al. Protective Effect of the BSYZF-Contained Serum and its Subgroups on Aβ25-35 Induced NG108-15 Cells Injure[J]. Chinese journal of experimental traditional medical formulae, 2002, 8(5): 27-30. DOI：

摘要

目的:研究中药补肾益智方拆方亚组的含药血清对AD细胞模型生长、分化等方面的影响

探讨该方药物的配伍规律。方法:将补肾益智方拆分为补肾组、益气养血组和去冰片组(即补肾组+益气养血组)等3个亚组

连同原方组共4组对大鼠灌胃给药分离药物血清。在含各组血清的培养液中

加入Aβ25-35

观察NG108-15细胞的生长状态、细胞增殖数、存活率

突起率及突起平均长度。结果:与AD细胞模型组相比

补肾益智方及各亚组含药血清都能在一定程度上抑制Aβ25-35对细胞的损伤作用

但各组情况有所不同。各组含药血清对细胞的保护作用由强至弱依次是去冰片组>补肾益智方组>补肾组>益气养血组。结论:补肾药配伍益气养血药可增强对Aβ25-35损伤NG108-15细胞的保护作用

其中以补肾药的作用为主

方中冰片的功效有待进一步研究。

Abstract

To study the effects of the BuShenYiZiFang-contained serum (BSYZF) and its subgroups on the differentiation and growth of NG108-15 cells injured with Aβ25-35

and to investigate compatible effects of BSYZF.BSYZF was divided into three subgroups:BUSHEN group

YIQIYAANGXUE group

QUBINGPIAN group (BUSHEN plus YIQYANGXUE

i.e.deleted borneol BSYXF).Four groups (BSYXF and its three subgroups) serum containing correspondent drugs were collected from rats

respectively

and used to culture cells.NG108-15 cells were cultured with Aβ25-35 for establishing cell model of Alzheimer's disease (AD).The cell morphology

cell viability and proliferation

and neurite outgrowth were observed.The results showed that all the herbage-contained serum could protect NG108-15 cells from Aβ25-35 neurotoxicity and the QUBINGPIAN was likely to have the best protective effect.The protective effects of the four groups were in the order:QUBINGPIAN>BSYZF>BUSHEN>YIQAIYANGXUE.

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