Protective Effect of Naohuandan on the Impairment of Cortial and Hippocampal Neuron Induced by Beta-amy Oid Protein

WEI Chang-xiu; LI Qing-ming; FU Yu-ru

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Protective Effect of Naohuandan on the Impairment of Cortial and Hippocampal Neuron Induced by Beta-amy Oid Protein

更新时间：2024-01-04

- Protective Effect of Naohuandan on the Impairment of Cortial and Hippocampal Neuron Induced by Beta-amy Oid Protein
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 10, Issue 3, Pages: 18-20(2004)
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- Published：2004
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WEI Chang-xiu, LI Qing-ming, FU Yu-ru. Protective Effect of Naohuandan on the Impairment of Cortial and Hippocampal Neuron Induced by Beta-amy Oid Protein[J]. Chinese journal of experimental traditional medical formulae, 2004, 10(3): 18-20.
DOI：

WEI Chang-xiu, LI Qing-ming, FU Yu-ru. Protective Effect of Naohuandan on the Impairment of Cortial and Hippocampal Neuron Induced by Beta-amy Oid Protein[J]. Chinese journal of experimental traditional medical formulae, 2004, 10(3): 18-20. DOI：

摘要

目的:探讨中药复方脑还丹对Aβ诱导的大脑皮质和海马神经元损害的作用。方法:采用MTT法及NSE免疫组化方法观察脑还丹药物血清对经Aβ25-35处理的原代培养的新生大鼠大脑皮质和海马神经元的影响。结果:体外培养的新生大鼠大脑皮质和海马神经元经Aβ25-35处理后

活细胞数减少

而脑还丹含药血清能够促进神经元的存活率以及促进神经元的生长发育

与对照组相比有显著性差异(P<0.05)。结论:中药复方脑还丹能够减轻Aβ对大脑皮质和海马神经元的毒性作用。

Abstract

Using thiazolyl blue colorimetry(MTT) and NSE immunohistochemistry staining to observe the effect of Naohuandan on the impairment induced by beta-amyloid protein(A β)of primary cultured cortial and hippocampal neurons

we found that when treated with A β

some neurons dead

As compared with those、with non-drug containing serum

Naohuandan containing serum treament could promote the survival

the growth and the development of neurons.The results indicated that Naohuandan could reduce the neurotoxin of A β to cortial and hippocampal neurons.

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