Effect of Active Fraction of Tiaoxin Recipe on Long-term Potentiation of CA1 in Rat Hippocampal Slices

QIAO Hai-fa; YANG Sheng; ZHOU Wen-xia; ZHANG Yong-xiang

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Effect of Active Fraction of Tiaoxin Recipe on Long-term Potentiation of CA1 in Rat Hippocampal Slices

更新时间：2024-01-04

- Effect of Active Fraction of Tiaoxin Recipe on Long-term Potentiation of CA1 in Rat Hippocampal Slices
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 11, Issue 1, Pages: 31-34(2005)
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- Published：2005
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QIAO Hai-fa, YANG Sheng, ZHOU Wen-xia, et al. Effect of Active Fraction of Tiaoxin Recipe on Long-term Potentiation of CA1 in Rat Hippocampal Slices[J]. Chinese journal of experimental traditional medical formulae, 2005, 11(1): 31-34.
DOI：

QIAO Hai-fa, YANG Sheng, ZHOU Wen-xia, et al. Effect of Active Fraction of Tiaoxin Recipe on Long-term Potentiation of CA1 in Rat Hippocampal Slices[J]. Chinese journal of experimental traditional medical formulae, 2005, 11(1): 31-34. DOI：

摘要

目的:研究调心方活性部位A对大鼠海马脑片诱发长时程增强(LTP)效应的影响。方法:采用细胞外微电极记录技术

记录大鼠海马脑片CA1区诱发群峰电位(PS)

然后施以100Hz

100串的强直刺激诱发LTP。结果:调心方活性部位A对大鼠海马脑片正常PS的形状、幅度无影响

提示并不影响海马的基础突触传递。给予强直刺激后

高浓度活性部位A可以明显增大LTP幅度

提示具有促进和维持LTP的作用。结论:调心方活性部位A可能是调心方促进和维持大鼠海马脑片诱发LTP的有效成分之一

对LTP的促进作用也是调心方活性部位A益智作用的机制之一。

Abstract

Aim:To investigate the active fraction A(TRX-A) of Tiaoxin Recipe(TXR) on long-term potentiation(LTP) of CA1 area in the rat hippocampl slices.Methods:LTP in CA1 area of rat hippocampal slices

which was induced by high frequency stimulation(100Hz

100pulses)

was recorded with extracellular recording technique.Results:TXR-A or TXR showed no effect on baseline synaptic responses.Compared with the slices pre-incubated and perfused with decoction-free artificial cerebrospinal fluid(ACSF)

population spike(PS) amplitude of slices exposed to TXR-A or TXR ACSF was significantly increased after high frequency stimulation.Conclusion:TXR-A is one of TXR active fractions which facilitate LTP in CA1 area of slices from rat.

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