Comparision of Xuanfa Moyuan Preparation and Common Threewinnut Root Treating CIA Rat

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Comparision of Xuanfa Moyuan Preparation and Common Threewinnut Root Treating CIA Rat

更新时间：2024-01-04

- Comparision of Xuanfa Moyuan Preparation and Common Threewinnut Root Treating CIA Rat
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 8, Issue 4, Pages: 21-23(2002)
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- Published：2002
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Comparision of Xuanfa Moyuan Preparation and Common Threewinnut Root Treating CIA Rat[J]. Chinese journal of experimental traditional medical formulae, 2002, 8(4): 21-23.
DOI：

Comparision of Xuanfa Moyuan Preparation and Common Threewinnut Root Treating CIA Rat[J]. Chinese journal of experimental traditional medical formulae, 2002, 8(4): 21-23. DOI：

摘要

探讨宣发膜原方对CIA的治疗机理

为研究RA的发病和损伤机理提供实验依据。以CIA作为RA的动物模型

对比研究宣发膜原方和雷公藤制剂对CIA大鼠免疫指标的影响。宣发膜原方和雷公藤制剂都可以减轻CIA大鼠病理损伤

增加血清中IFN-γ

降低TNF-α和抗CII抗体

并且雷公藤制剂对CIA的治疗效果不如宣发膜原方作用快。宣发膜原法能够减轻CIA病理损伤

调节CIA大鼠免疫功能。

Abstract

To probe the mechanism of Xuanfa Moyuan preparation treating rats collagen-Ⅱinuced arthritis(CIA)which is similar to human RA

rats were immunized with the complex of collagen-Ⅱand complete Frund’s adjuvant.Theimmunological and morphological changes in the ratswere observed after the ratswere treatedwith XuanfaMoyuan prepa-ration common threewingnut root

damages of CIA rats joints were relieved

TNF-α and anti-CII antibody in the serumshowed some decrease.But IFN-γ showed some increase.XuanfaMoyuan prepartion could relieve the damages of CIArat’ s joints and regulate the immunology activity of CIA rats.And Xuanfa moytan preparation could produces effect morequickly than common threewingnut root.

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