Effect on Prostaglandin Dehydrogenase in Hypothalamus in Both the Pyretic and Hypothermia Rats by Guizhi Tang
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Effect on Prostaglandin Dehydrogenase in Hypothalamus in Both the Pyretic and Hypothermia Rats by Guizhi Tang
Chinese Journal of Experimental Traditional Medical FormulaeVol. 9, Issue 1, Pages: 27-30(2003)
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Published:2003
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LI Cang-hai, Huo Hai-ru, Zhou Jun, et al. Effect on Prostaglandin Dehydrogenase in Hypothalamus in Both the Pyretic and Hypothermia Rats by Guizhi Tang[J]. Chinese journal of experimental traditional medical formulae, 2003, 9(1): 27-30.
DOI:
LI Cang-hai, Huo Hai-ru, Zhou Jun, et al. Effect on Prostaglandin Dehydrogenase in Hypothalamus in Both the Pyretic and Hypothermia Rats by Guizhi Tang[J]. Chinese journal of experimental traditional medical formulae, 2003, 9(1): 27-30.DOI:
Effect on Prostaglandin Dehydrogenase in Hypothalamus in Both the Pyretic and Hypothermia Rats by Guizhi Tang
To further highlight Guizhi Tang's mechanism of dual-directional thermoregulation
the 15-PGDH activity in pyretic and hypothermia rats was detected using isotopic tracing assay.A decrease in PGDH activity paralleled with a pronounced rise in body temperature in rat hypothalamus 5.5hr after a s.c. yeast-injection was observed and both the responses was counteracted by the treatment of Guizhi Tang orally in a dose-dependent manner.Aminopyrine induced a tendency to enhance PGDH activity and a marked drop in body temperature meanwhile in rats 1 hr later
but there was a poor relation between changes in body temperature and in activity of PGDH evoked by Guizhi Tang.Present data suggest that PGDH in hypothalamus may play a role in thermoregulation in rats and is also a target of antipyretic action of Guizhi Tang
but it probably does not contribute to anti-hypothermia action of Guizhi Tang.
Effect on the Time Course of the Cerebral Prostaglandin Dehydrogenase in Pyretic Rats by Guizhi Tang
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Effect of Guizhi Tang on CREB in Hypothalamus in Both Fever and Hypothermia Rats
Effect of Guizhi Tang on the PKA and PKC Activities of Hypothalamus in Hypothermia Rats
Component Analysis of Anmeidan and Its Mechanism in Regulating ERK1/2/MNK/ELF4E Signaling Pathway to Improve Circadian Rhythm in Insomnia Rats
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LI Lan-fang
Qi Yun
ZHOU Jun1
2
Li Cang-hai1
HUO Hai-ru1
LI Lan-fang1
JIANG Nan1
Related Institution
Key Laboratory of Chinese Medicine Resource and Compound Prescription, Ministry of Education, Hubei University of Chinese Medicine
Engineering Research Center of Traditional Chinese Medicine Protection Technology and New Product Development for the Elderly Brain Health, Ministry of Education, Hubei University of Chinese Medicine
Hubei Shizhen Laboratory
Henan University of Chinese Medicine
Liaoning University of Traditional Chinese Medicine(TCM)