StudyⅡon Substance Basis and Mechanism of Action of Danggui Shaoyao San in the Protection and Treatment of Senile Dementia———Similar Efficacy in the Treatment of Brain Aging
|更新时间:2024-01-04
|
StudyⅡon Substance Basis and Mechanism of Action of Danggui Shaoyao San in the Protection and Treatment of Senile Dementia———Similar Efficacy in the Treatment of Brain Aging
Chinese Journal of Experimental Traditional Medical FormulaeVol. 8, Issue 4, Pages: 18-20(2002)
作者机构:
作者简介:
基金信息:
DOI:
CLC:
Published:2002
稿件说明:
移动端阅览
LIN Zhi-hong, ZHU Dun-ni, YAN Yong-qing, et al. StudyⅡon Substance Basis and Mechanism of Action of Danggui Shaoyao San in the Protection and Treatment of Senile Dementia———Similar Efficacy in the Treatment of Brain Aging[J]. Chinese journal of experimental traditional medical formulae, 2002, 8(4): 18-20.
DOI:
LIN Zhi-hong, ZHU Dun-ni, YAN Yong-qing, et al. StudyⅡon Substance Basis and Mechanism of Action of Danggui Shaoyao San in the Protection and Treatment of Senile Dementia———Similar Efficacy in the Treatment of Brain Aging[J]. Chinese journal of experimental traditional medical formulae, 2002, 8(4): 18-20.DOI:
StudyⅡon Substance Basis and Mechanism of Action of Danggui Shaoyao San in the Protection and Treatment of Senile Dementia———Similar Efficacy in the Treatment of Brain Aging
To observe the similarity between Danggui Shaoyao San(DSS) and FBD made up ofporia
rhizoma atractylodis macrocephalae and radix angelicae sinensis in the treatment of brain aging
the micewith innate memory dysfunctionwere screened inwatermaze test beforehand
then brain agingmodelwas establishedwith D-galactose(D-gal)for 6 weeks.Once each weekend from 3rd to 6th week
the stimulate time taken by mice to avoid passively electric stimulate had beendetected in shuttle box test for 4 times in total.In addition
soluble protein content in cortex and hippocampus
melondial-dehyde(MDA)content in cortex
and acetycholinesterase(AchE)activity in hippocampus were examined after memory detection.Results showed 2.3g/kg FBD and 2.8g/kg DSS shortened stimulate time taken by brain aging mice
and inhibitedobviously the decreasingsoluble protein content
the increasingMDAcontent
and the growingAchE activity induced byD-gal in cortex and hippocampus(p<0.05 or 0.01).
Establishment and Evaluation of Rat Model of Myocardial Ischemia-reperfusion Injury with Phlegm and Blood Stasis Blocking Collaterals Syndrome Based on Metabolomics
Establishment and Evaluation of Rat Model of Acute Myocardial Infarction in Coronary Heart Disease with Qi and Yin Deficiency Syndrome Based on Sleep Deprivation Combined with Coronary Artery Ligation
Analysis of Animal Model of Chronic Heart Failure Based on Combination of Diseases and Syndromes of Traditional Chinese Medicine and Western Medicine
Evaluation of Animal Models with Diminished Ovarian Reserve Based on Clinical Disease and Syndrome Characteristics of Traditional Chinese Medicine and Western Medicine
Editorial Explanation of Guidelines for Establishing Animal Models of Rheumatoid Arthritis with Cold-dampness Obstruction Syndrome and Dampness-heat Obstruction Syndrome
Related Author
HU Longxiao
GAO Jiabei
MA Weihao
LU Jieming
GAO Yunxiao
YUAN Yue
ZHANG Qiuyan
CHEN Xiaoxiao
Related Institution
School of Clinical Medicine,Beijing University of Chinese Medicine
Beijing Key Laboratory of Chinese Materia Pharmacology,National Clinical Research Center of Traditional Chinese Medicine for Cardiovascular Diseases,Institute of Basic Medical Sciences, Xiyuan Hospital,China Academy of Chinese Medical Sciences
Natural History Museum of China
Institute of Basic Medical Sciences,Xiyuan Hospital,China Academy of Chinese Medical Sciences